Prof. Richard Sindelar

Uppsala University Children's Hospital

CV

EDUCATION AND CLINICAL WORK
1990     Medical Examination, University of Linköping, Sweden
1992     Licensed Medical Doctor after a 2-year residency at Västervik Hospital, Västervik
1998     Specialist in Pediatrics, University Children’s Hospital, Uppsala, Sweden
2000    Specialist in Neonatology, University Children’s Hospital, Uppsala, Sweden
2000-present     Senior Consultant in Neonatology with senior on-call responsibility since 1996, Neonatal Intensive Care Medicine, University Children’s Hospital, Uppsala
1998-present     On-call helicopter/airplane doctor for transportation of newborn infants in Sweden, Uppsala University Hospital, Uppsala
2004-present    Head of National Centre for Children with Phrenic Nerve Stimulator, together with Associate Professor Anders Jonzon
2004-present    Medical Director of Neonatal Respiration, Circulation and Pharmacology, NICU, University Children’s Hospital, Uppsala
2017-present     Medical Director and Principal Investigator for Sever BPD Center, University Children’s Hospital, Uppsala, as part of the BPD Collaborative including NICUs at 19 University Hospitals in USA and one in Sweden  
      
RESEARCH TRAINING AND POSITION
1997-2001     PhD studies at the Department of Women’s and Children’s Health and at the Department of Physiology and Medical Biophysics, Uppsala University
2001-05-14    PhD degree in Pediatrics and Physiology, Uppsala University
2002-2004      Postdoctoral fellow at the Division of Pulmonary Biology, Children’s Hospital Medical Center, Cincinnati, USA, under the supervision of Professor Alan H. Jobe
2004-2017      Assistant Professor and Senior Researcher in Pediatrics, Uppsala University, Uppsala
2017-04-20     Associate Professor in Pediatrics, Uppsala University, Uppsala

PUBLICATIONS

Publications

1.    Schulze A, Jonzon A, Sindelar R, Schaller P, Dammann V, and G Sedin. Assisted mechanical ventilation using combined elastic and resistive unloading in cats with severe respiratory failure. Acta Paediatr 88(6): 636-41, 1999    
2.    Sindelar R, Ehrhardt H, Jonzon A, Rieger-Fackeldey E, Schaller P, Schulze A, and G Sedin. Effects of the inspiratory pressure waveform during assisted mechanical ventilation on pulmonary stretch receptor and phrenic nerve activity in cats. Crit Care Med 29(6): 1207-1214, 2001
3.    Rieger-Fackeldey E, Sindelar R, Jonzon A, and G Sedin. Pulmonary stretch receptor activity during partial liquid ventilation in cats with healthy lungs. Biol Neonate 86(2):73-80, 2004
4.    Sindelar R, Jonzon A, Schulze A, and G Sedin. Surfactant replacement recovers the activity of pulmonary stretch receptors in surfactant depleted cats on CPAP. J Appl Physiol 100(2): 594-601, 2006
5.    Sindelar R, Rieger-Fackeldey E, Jonzon A, Schaller P, Schulze A, and G Sedin. Maintained inspiratory activity during proportional assist ventilation in surfactant-depleted cats early after surfactant instillation: phrenic nerve and pulmonary stretch receptor activity. Respir Res 7(1): 38, [p.1-14], 2006
6.    Rieger-Fackeldey E, Sindelar R, Jonzon A, and G Sedin. Inhibition of spontaneous breathing during gas ventilation (GV) and partial liquid ventilation (PLV) in cats with healthy and lavaged lungs. Respir Res  6(1):24, [p.1-8], 2006  
7.    Sindelar R, Rieger-Fackeldey E, Sedin G, and A Jonzon. Pressure increase due to hydrostatic pressure of perfluorocarbon – not obvious as sensed by pulmonary stretch receptors.  Am J Respir Crit Care Med 175(3): 290, 2007
8.    Kramer BW, Joshi SN, Moss TJ, Newnham JP, Sindelar R, Jobe AH, and SG Kallapur. Endotoxin-induced maturation of macrophages in preterm fetal sheep lung. Am J Physiol Lung Cell Mol Physiol 293(2): L345–L353, 2007
9.    Sindelar R, Rieger-Fackeldey E, Sedin G, and Jonzon A. Bronchopulmonary C fibers modulate the breathing pattern in surfactant-depleted juvenile cats. Respir Physiol Neurobiol 160(3): 341–349, 2008
10.    van Kaam AH et al, on behalf of the Neovent Study Group (R Sindelar). Ventilation Practices in the Neonatal Intensive Care Unit: A Cross-Sectional Study. J Pediatr 157 (5): 767-771, 2010
11.    van Kaam AH et al, on behalf of the Neovent Study Group (R Sindelar). Surfactant replacement therapy in preterm infants: an European survey. Neonatol 100 (1):71-77, 2011
12.    Munsters JMA, Wallström L, Ågren J, Norsted T, and R Sindelar. Skin conductance measurements as pain assessment in newborn infants born at 22-27 weeks gestational age at different postnatal age. Early Hum Dev. 2012 Jan;88(1):21-6
13.    Olsson KW, Jonzon A, and R Sindelar. A High Ductal Flow Velocity is Associated with Successful Pharmacological Closure of Patent Ductus Arteriosus in Infants 22-27 Weeks Gestational Age. Crit Care Res Practice, Volume 2012 Dec, Article ID 715265, 6 pages, 2012
14.    van Kaam AH et al on behalf of the Neovent Study Group (R Sindelar). Incidence of hypo- and hyper-capnia in a cross-sectional European cohort of ventilated newborn infants. Arch Dis Child Fetal Neonatal Ed. 98(4):F323-6, 2013
15.    Olsson KW, and R Sindelar. Future benefits of sequential echocardiography - unmasking the indications for treatment of PDA in extemely preterm infants. Neonatology. 108(2):99, 2015
16.    Stålhammar ME, Sindelar R, Douhan Håkansson L. Neutrophil Receptor Response to Bacterial N-formyl Peptides is Similar in Term Newborn Infants and Adults in Contrast to IL-8. Scand J Immunol. 84(6):332-337, 2016
17.    Stålhammar M, Douhan Håkansson L, Jonzon A, and R Sindelar. Differential neutrophil chemotactic response towards IL-8 and bacterial N-formyl peptides in term newborn infants. Ups J Med Sci. 122(1):35-42, 2017
18.    Stålhammar M, Douhan Håkansson L and R Sindelar. Bacterial N-formyl Peptides Reduces Neutrophil Respiratory Burst in Response to PMA and E.coli in Term Newborn Infants and Adults. Scand J Immunol. 85(5):365-37, 2017
19.    Frid I, Ågren J, Kjellberg M, Normann E, and R Sindelar. Critically ill neonates displayed stable vital parameters and reduced metabolic acidosis during neonatal emergency airborne transport in Sweden. Acta Paediatr. 107(8): 1357-1361, 2018
20.    Markasz L, Savani RC, Sedin G, and R Sindelar. RHAMM expression in bronchiolar epithelium of neonates negatively correlates with lung air content. Early Hum Develop. Dec;127:58-68, 2018
21.    Backes CH, Söderström F, Ågren J, Sindelar R, Bartlett CW, Rivera BK, Mitchell CC, Frey H, Shepherd EG, Nelin LD, and E Normann. Outcomes Following a Comprehensive versus a Selective Approach for Infants Born at 22 Weeks of Gestation. J Perinatol. Jan;39(1):39-47, 2019
22.    Veneroni C, Wallström L, Sindelar R, and R Dellaca’. Oscillatory respiratory mechanics on the first day of life improves prediction of respiratory outcomes in extremely preterm newborns. Pediatr Res. Feb;85(3):312-317, 2019
23.    Olsson KW, Jonzon A, and R Sindelar. Early haemodynamically significant patent ductus arteriosus does not predict future persistence in extremely preterm infants. Acta Paediatr. Feb 12; 108(9):1590–1596, 2019
24.    Söderström F, Normann E, Holmström G, Larsson E, Ahlsson F, Sindelar R, Ågren J. Reduced rate of retinopathy of prematurity after implementing lower oxygen saturation targets. J Perinatol. Mar;39(3):409-414, 2019
25.    Olsson KW, Jonzon A, Larsson A, and R Sindelar. Exploration of Potential Biochemical Markers for Persistence of Patent Ductus Arteriosus in Preterm Infants at 22-27 Weeks’ Gestation. Pediatr Res. Sep;86(3):333-338, 2019
26.    Olsson KW, Larsson A, Jonzon A, Sindelar R. Insights image for exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22-27 weeks' gestation. Pediatr Res. Sep;86(3):413, 2019
27.    van Kaam AH, De Luca D, Hentschel R, Hutten J, Sindelar R, Thome U, and LJI Zimmermann. Modes and strategies for providing conventional mechanical ventilation in neonates. Pediatr Res. Nov 30. doi: 10.1038/s41390-019-0704-1. Review. 2019
28.    Wallström L, Veneroni C, Zannin E, Dellaca’ R, and R Sindelar. Forced Oscillation Technique for Optimising PEEP in Ventilated Extremely Preterm Infants.  Eur Respir J. May 7;55(5):1901650, 2020
29.    Rieger-Fackeldey E, Jonzon A, Schulze A, Sedin G, and R Sindelar. Pulmonary Stretch Receptor Activity and Partial Liquid Ventilation during different pressure waveforms. Respir Physiol Neurobiol. May;276:103413, 2020
30.    Markasz L, Olsson KW, Holmström G, and R Sindelar. Cluster analysis of early postnatal biochemical markers may predict development of retinopathy of prematurity. Trans Vis Sci Tech. Dec 8;9(13):14, 2020
31.    Blomqvist YT, Dawit F, Karlsson V, Sindelar R, and J Ågren. Physiological stability in very preterm infants during skin-to-skin care as assessed by near-infrared spectroscopy. Adv Neonatal Care. Dec;20(6):495-498, 2020
32.    Markasz L, Savani RC, Jonzon A, and R Sindelar. CD44 and RHAMM expression patterns in the human developing lung. Pediatr Res. Jan;89(1):134-142, 2021
33.    Olsson KW, Youssef S, Kjellberg M, Raaijmakers R, and R Sindelar. A matched case control study of surgically and non-surgically treated patent ductus arteriosus in extremely preterm infants. Front Pediatr. Mar 18;9:648372, 2021
34.    Wallström L, Sjöberg A, and R Sindelar. Early volume targeted ventilation in preterm infants born at 22-25 weeks of gestational age. Pediatr Pulmonol. May;56(5):1000-1007, 2021
35.    Sindelar R, Shepherd EG, Ågren J, Panitch HB, Abman SH, and LD Nelin; on behalf of the BPD Collaborative. Established Severe BPD – Is There a Way Out? Change of Ventilatory Paradigms. Pediatr Res, 2021 May 19. doi: 10.1038/s41390-021-01558-8
36.    Sindelar R, McKinney RL, Wallström L, and M Keszler. Proportional assist and neurally adjusted ventilation: current clinical knowledge and future trials in newborn infants. Pediatr Pulmonol. Jul; 56(7):1841–1849, 2021
37.    Hoffsten A, Markasz L, Ericson K, Nelin L, and R Sindelar. The Value of Autopsy in Preterm Infants at a Swedish Tertiary Neonatal Intensive Care Unit 2002-2018. Sci Rep. Jul 8;11(1):14156, 2021
38.    McKinney RL, Keszler M, Truog W, Norberg, M, Sindelar R, Wallström L,  Schulman B, Gien J, Abman SH; on behalf of the BPD Collaborative. Multicenter experience with neurally adjusted ventilatory assist in infants with evolving or established bronchopulmonary dysplasia. Am J Perinatol. Aug;38(S 01):e162-e166, 2021
39.    Sindelar R, Nakanishi H, Stanford AH, Colaizy TT, and JM Klein. Respiratory Management for Extremely Premature Infants born at 22 to 23 weeks of Gestation in Proactive Centers in Sweden, Japan, and USA. Semin Perinatol. 2021 Nov 10:151540. doi: 10.1016/j.semperi.2021.151540. Epub ahead of print.
40.    Backes CH, Sindelar R, and A Janvier. Management, treatment and ethical considerations in the care of mother-infant dyads at less than 25 weeks of gestations – Part I. Semin Perinatol. 2021 Nov 9:151530. doi: 10.1016/j.semperi.2021.151530. Epub ahead of print.  
41.    Backes CH, Sindelar R, Janvier A. Opportunities and recommendations in the care of mother-infant dyads at less than 25 weeks of gestation. Semin Perinatol. 2021 Nov 16:151552. doi: 10.1016/j.semperi.2021.151552. Epub ahead of print.
42.    Backes CH, Sindelar R, Janvier A. Management, treatment and ethical considerations in the care of mother-infant dyads at less than 25 weeks of gestation – Part II. Semin Perinatol. 2021 Nov 10:151535. doi: 10.1016/j.semperi.2021.151535. Epub ahead of print.
43.    McKinney RL, Napolitano N, Levin J, Kielt M, Abman SH, Cuevas Guaman M, Rose RS, Courtney SE, Matlock D, Agarwal A, Leeman K, Sanlorenzo LA, Sindelar R, Collaco JM, Baker CD, Hannan KE, Douglass M, Eldredge L, Lai K, McGrath-Morrow S, Tracy MC, Truog W, Lewis T, Murillo A, and M Keszler, on behalf of the BPD Collaborative. Ventilatory strategies in infants with established severe bronchopulmonary dysplasia: A multicenter point prevalence study. J Pediatr. 2021 Oct 26:S0022-3476(21)01029-5
44.    Hoffsten A, Markasz L, Engstrand Lilja H, Olsson KW, and R Sindelar. Early Postnatal Comprehensive Biomarkers Cannot Identify Extremely Preterm Infants at High Risk of Developing Necrotizing Enterocolitis. Front Pediatr. 2021 Oct 22;9:755437
45.    Söderström F, Ågren J, and R Sindelar. Early extubation is associated with shorter duration of mechanical ventilation and lower incidence of bronchopulmonary dysplasia. Early Hum Dev. 2021 Dec;163:105467.
46.    Tsolakis N, Sindelar R, Markström A, Nilsson P, and A Jonzon. Strategy of changing from tracheostomy and non-invasive mechanical ventilation to diaphragm pacing in children with congenital central hypoventilation syndrome. Acta Paediatr, 2022 Jan 18. doi: 10.1111/apa.16256.
47.    Erdeve Ö, Ovali F, Sallmon H, Atasay B, Okulu E, Singh Y, Bulbul A, Terrin G, Sindelar R, Oncel MY, and R Clyman. PDA update and what’s next? Accepted for publication in Turkish Arch Pediatr, 2022
48.    Norman M, Jonsson B, Wallström L, and R Sindelar. Respiratory support of infants born at 22-24 weeks of gestational age. Invited review in Sem Fet Neo Med, 2022
49.    Diderholm B, Normann E, Ahlsson F, Sindelar R, Ågren J. The impact of restricted versus liberal early fluid volumes on plasma sodium, weight change, and short term outcomes in ex-tremely preterm infants. Submitted to Nutrients, 2022
50.    Sindelar R, Wallström L, McKinney RL, and M Keszler. Response: Diaphragm electrical activity target during NAVA: one size may not fit all. Ped Pulm, 2022
BOOK CHAPTERS AND THESIS
51.    Sindelar R, Ewald U. Kapitel 2. Störningar i andning och cirkulation hos nyfödda barn. Akut Pediatrik. Ed Larsson A, Lindquist B, Norgren S. Liber, 2 upplagan, Stockholm, s.29-43, 2007
52.    Sindelar R. Kapitel Neonatalperioden. Andningsstörningar. Cirkulationsstörningar. Terapikompendium i pediatrik. Inst för kvinnors och barns hälsa,  Uppsala, s. 76-82 samt 88-89, 2007
53.    Munsters JMA, and R Sindelar. Skin conductance measurements (SCM) as pain assessment in newborn infants born at 22-27 gestational weeks (GA) at different postnatal ages (PNA). Graduation Work, Medical School, Radboud University and Uppsala University, 2008
54.    Olsson KW, Jonzon A, and R Sindelar. Early clinical predictors for failure of pharmacological ductus arteriosus treatment in extremely preterm infants. Graduation Work, Medical School, Uppsala University, 2009
55.    Sindelar R, och A Jonzon. Frenicus stimulator - ett alternativ till hemrespirator. Barnläkaren 3: s. 5-6, 2009
56.    Ley D, Sindelar R. Kapitel 3. Neonatala cirkulationsstörningar inkluderande hypovolemi, hypotension och PDA. Akut Pediatrik. Ed Norman M, Norgren S. Liber, Stockholm, s. 37-44, 2010; 2:a revision 2014
57.    Sindelar R, Jonsson B. Kapitel 2. Andningsstörningar hos nyfödda. Akut Pediatrik. Ed Norman M, Norgren S. Liber, Stockholm, s.24-36, 2010; 2:a revision 2014
58.    af Winklerfelt C, Håkansson S, Serenius F, and R Sindelar. Early inotropic treatment of blood pressure in extremely preterm newborn infants - does it matter? Graduation Work, Biomedical School, Uppsala University, 2011  
59.    Nydert P, och R Sindelar. Enteral läkemedelsadministrering till barn i nyföddhetsperioden. Bakgrundsinformation. Information från Läkemedelsverket nr 2, s. 43-46, 2013
60.    Sindelar R, Expertgrupp LMV. Läkemedelsadministrering via sond. Behandlingsrekommendation, Information från LMV nr 2, s. 1-20, 2013
61.    Sindelar R, Wallström L. Neonatala andningsstörningar. Terapikompendium. Uppsala, s. 71-77, 2013
62.    Sindelar R. Neonatal hypotension. Terapikompendium. Uppsala, s. 78-80, 2013
63.    Sindelar R. Pulmonell hypertension hos nyfödda. Terapikompendium. Uppsala, s. 77-78, 2013
64.    Sindelar R, Jonzon A. PDA hos underburna barn. Terapikompendium. Uppsala, s. 80-82, 2013
65.    Sindelar R, Jonzon A. Diafragmal pacing och kongenital centralt hypoventilationssyndrom. Terapi-kompendium. Uppsala, s. 103-106, 2013
66.    Sindelar R. Expertgrupp lunga. Lungsjukdomar och andningsunderstöd. Vård av extremt för tidigt födda barn - En vägledning för vården av barn födda före 28 fullbordade graviditetsveckor, SoS, s. 43-49, 2014
67.    Klintemyr S, and R Sindelar. Evaluation of causes for accidental extubations in newborn infants on invasive ventilation with special respect to pain relief and complications during intubation  - a prospective qualitative study in a NICU environment. Graduation Work, Biomedical School, Uppsala University, 2012
68.    Winderud M, Sindelar R, and A Jonzon. Diaphragm Pacing in Children with Congenital Central Hypoventilation Syndrome. Graduation Work, Medical School, Uppsala University, 2012
69.    Groth E, Stålhammar M, and R Sindelar. Influence of Early Osmolar Changes on the Outcome of Extremely Preterm Newborn Infants (GA ≤ 27 +6) in Terms of Morbidity and Mortality. Graduation Work, Medical School, Uppsala University, 2013
70.    Hermodsson J, Wallström L, and R Sindelar. Use of forced oscillatory technique (FOT) to estimate the optimal PEEP in premature newborns with ventilatory assistance. Graduation Work, Medical School, Uppsala University, 2014
71.    Frid I, Ågren J, Kjellström M, and R Sindelar. University Children’s Hospital airborne neonatal transportation during 20 years – Safe Transportation of Preterm Infants Postnatally. Graduation Work, Medical School, Uppsala University, 2015
72.    Youssef S, Kjellström M, Olsson KW, and R Sindelar. Outcomes after surgically treated persisten patent ductus arteriosus in extremely preterm newborn infants. Graduation Work, Medical School, Uppsala University, 2018.
73.    Sjöberg A, Wallström L, and R Sindelar. Can early instituted Volume Guarantee Ventilation improve short and long-term outcomes in extremely premature infants? Graduation Work, Medical School, Uppsala University, 2018
74.    Ley D, Sindelar R. Kapitel 3. Neonatala cirkulationsstörningar inkluderande hypovolemi, hypotension och PDA. Akut Pediatrik. Ed Norman M, Norgren S. Liber, Stockholm, s. 38-45, 3:e revision, 2019
75.    Sindelar R, Jonsson B. Kapitel 2. Andningsstörningar hos nyfödda. Akut Pediatrik. Ed Norman M, Norgren S. Liber, Stockholm, s.23-37, 3:e revisionen, 2019
76.    Hoffsten A, Markasz L, Ericson K, and R Sindelar. Causes of Infant Mortality in Preterm Infants Born 2002-2009 and 2011-2018 at a Tertiary Neonatal Intensive Care Unit - Changes over Time in Relation to Maturity and Survival. Graduation Work, Medical School, Uppsala University, 2020
77.    Sindelar R, Wallström L. Neonatala andningsstörningar. Terapikompendium Pediatrik. Uppsala Akademiska Barnsjukhus, s. 68-73, 2020
78.    Sindelar R. Pulmonell hypertension hos nyfödda. Terapikompendium Pediatrik. Uppsala Akademiska Barnsjukhus, s. 74, 2020
79.    Sindelar R, Gialmas S. Cirkulationsstörning och hypotension hos nyfödda. Terapikompendium Pediatrik. Uppsala Akademiska Barnsjukhus, s. 75-77, 2020
80.    Olsson KW, Sindelar R. Öppetstående duktus arteriosus (PDA) hos underburna barn. Terapikompendium Pediatrik. Uppsala Akademiska Barnsjukhus, s. 78-79
81.    Sindelar R. Respiratory gaseous exchange, oxygen and carbon dioxide transport: aspects relevant to neonatal pulmonology. Neonatal Pulmonology Module, Neonatal Online Training and Education (NOTE), Faculty of the European Society for Pediatric Society (ESPR)/ University of Southampton, 2021
82.    Sindelar R. Control of breathing mechanisms: developmental aspects. Neonatal Pulmonology Module, Neonatal Online Training and Education (NOTE), Faculty of the European Society for Pediatric Society (ESPR)/ University of Southampton, 2021
83.    Strömblad K, Naseh N, Penno E, and R Sindelar. Cranial Ultrasound in Very Preterm Infants - Is a Follow-up Examination at Term Age Necessary if the Initial Examination Shows Normal Results? Graduation Work, Medical School, Uppsala University, 2021
84.    Fureman E, Wallström L, and R Sindelar. Early initiation of Chronic Phase Ventilation in infants developing severe bronchopulmonary dysplasia – a descriptive cohort study. Graduation Work, Medical School, Uppsala University, 2021

MANUSCRIPTS READY FOR SUBMISSION AND MANUSCRIPTS IN PREPARATION
1.    Munsters JMA, Holmström G, and R Sindelar. Skin conductance measurements as pain assessment during eye examinations for retinopathy of prematurity. Under submission to Clin J Pain
2.    Wallström L, Jonzon A, Schulze A, and R Sindelar. Breathing Activity in the Transition from Assist Control to Proportional Assist Ventilation in Cats and Preterms. Ready for submission
3.    Cristea AI, Tracy MC, Bauer SE, Cuevas Guaman M, Welty SE, Baker CD, Bhombal S, Collaco JM, Courtney S, Eldredge L, Gibbs K, Hayden LP, Keszler M, Lai K, McGrath-Morrow SA, Moore PE, Rose R, Sindelar R Truog WE, Nelin LD, and SH Abman. Interdisciplinary Care - A Survey of the Bronchopulmonary Dysplasia Collaborative. Ready for submission
4.    Markasz L, and R Sindelar. Intracellular and extracellular type 4 collagen deposits in the human newborn lung dependent on postnatal age rather than gestational age. Ready for submission
5.    Kielt MJ, Hatch LD, Levin JC, Napolitano N, Baker CD, Eldredge LC, McGrath-Morrow SA, Collaco JM, Abman SH, Lai K, Rose RS, Keszler M, Sindelar R, Nelin LD, and RL McKinney. Classifying Multi-center Ventilation Strategies for Severe Bronchopulmonary Dysplasia by Hierarchical Clustering Analysis. In manuscript
6.    Söderström F, Sindelar R, Youssef S, Heimdahl M, Kjellberg M, Todorova D, Olsson KW, Mellander M, and R Raaijmakers. Patent ductus arteriosus in premature infants - to ligate or not to ligate? A retrospecive two center study (Gothenburg and Uppsala) of preterms born <27 weeks GA between 2010-2017. In manuscript
7.    Wallström L, Kielt M, Fureman E, Ejdersten J, Shepherd E, Nelin LD, and R Sindelar. Early application chronic phase ventilation in preterm infants with evolving severe bronchopulmonary dysplasia. In manusript
8.    Um Bergström P, Abrahamsson T, Björklund L, Löfberg L, Serenius F, and R Sindelar. Have different ventilatory strategies changed the incidence of bronchopulmonary dysplasia in extremley preterm infants in Sweden during a ten year period? EXPRESS 2. In manuscript
9.    Strömblad K, Naseh N,  Penno E, and R Sindelar. Cranial Ultrasound in Very Preterm Infants - Is a Follow-up Examination at Term Age Necessary if the Initial Examination Shows Normal Results? In manuscript
10.    Diderholm B, Groth E, Olsson KW, Ågren J, and R Sindelar. Influence of Early Osmolar Changes on the Outcome in Extremely Preterm Newborn Infants. In manuscript
11.    Sindelar R, and R Dellaca’. Pulmonary stretch receptor activity related to the energy stored in the normal and surfactant-depleted lung during inspiration. Abstract accepted/ In manuscript
12.    Markasz L, Johnsson H, Eriksson LE, and R Sindelar. Antenatal saline administration can influence the lung hyaluronan concentration and the lung water content at birth in preterm rabbit pups. In manuscript
13.    Kjellberg M, Frid I, Normann E, Ågren J, and R Sindelar. Luftburen regional transportverksamhet – 25 års erfarenhet av neonatala transporter. In manuscript
14.    Sindelar R and AH Jobe. Lung interstitial white blood cells after ventilation of intra-amniotically endotoxin exposed premature lambs. Abstract accepted/In manuscript
15.    Stålhammar M, Markasz L, Douhan Håkansson L, and R Sindelar. Compromised Ability to Modulate Neutrophil Respiratory Burst in Very Preterm Newborn Infants. In preparation
16.    Sindelar R and R Zetterstrom. Sir Adrian and sir Sherrington Nobel Prize 1932 – electrophysiological insights are still relevant for todays pediatric clinicians. In preparation
17.    Sindelar R, Hull W, and Jobe AH. Intra-amniotic endotoxin stimulates systemic anti-endotoxin antibody production in premature lambs with or without antenatal betamethasone. In preparation
18.    Sindelar R, Sedin G, and A Jonzon. The effect of a porcine surfactant on slowly adapting pulmonary stretch receptor activity during intermittent positive pressure ventilation with different lung inflation patterns in surfactant depleted cats. Abstract accepted/In preparation
19.    Sindelar R, Loudy D, and Jobe AH. Interstitial inflammatory cells and lung injury in endotoxin exposed preterm lambs: biochemical and automated image analysis of lung tissue. Abstract accepted/In preparation
20.    Sindelar R, Jobe AH, and Kramer BW. Occurrence of lipopolysaccharide binding protein (LBP) in lung tissue, amniotic fluid, alveolar wash and plasma after intra-amniotic endotoxin exposure of premature lambs. In preparation
21.    Markasz L, Sindelar R and RC Savani. Lung morphometric study of 3-nitrotyrosine occurrence in human neonatal lung injury. In preparation
    


PUBLISHED POPULAR SCIENCE
1.    Nilsson P, Sindelar R, Jonzon A. ”De kan dö om de somnar – Följ Rebeckas och Christoffers unika operationer till ett liv utan respirator”. Expressen, förstasidan samt s. 13-15, 17 januari, 2009.
2.    Törnered A, Kjellberg M, Sindelar R. Bronkopulmonell dysplasi. Kontakt, Nr 3, september, 2021

PUBLISHED AND PRESENTED ABSTRACTS SINCE 2002
1.    Rieger Fackeldey E, Sindelar R, Jonzon, A, and G Sedin. ”Pulmonary stretch receptor activity during partial liquid ventilation”. European Society of Pediatric Research Annual Meeting in Utrecht, 4-7 september 2002. Pediatr Res. 51(4):605 (abstract), 2002
2.    Sindelar R, Jonzon, A, and G Sedin. ”The activity of slowly adapting pulmonary stretch receptors (PSRs) reflects the changes in lung mechanics in small segments of the lung in a model of surfactant depleted lungs, before and after instillation of surfactant”. 17th International Workshop on Surfactant in Cagliari, September 24-26, 2002. Biol Neonate 81 (1): 37 (abstract), 2002
3.    Sindelar R, Jonzon, A, and G Sedin. “The activity of slowly adapting pulmonary stretch receptors (PSRs) reflects the changes in lung mechanics in a model of surfactant depleted lungs.” Midnight Sun School on Perinatal Cardiorespiratory Adaptation, Turku, June 14-16, 2002
4.    Sindelar R, Jonzon A, Schaller P, Schulze A, and G Sedin. “Breathing pattern and regulation of breathing during proportional assist ventilation (PAV) in surfactant-depleted cats.” Midnight Sun School on Perinatal Cardiorespiratory Adaptation, Turku, June 14-16, 2002
5.    Rieger Fackeldey E, Sindelar R, Jonzon, A, and G Sedin.“Pulmonary stretch receptor activity during partial liquid ventilation in cats.” Midnight Sun School on Perinatal Cardiorespiratory Adaptation, Turku, June 14-16, 2002
6.    Rieger Fackeldey E, Sindelar R, Jonzon, A, and G Sedin.“Inhibition of spontaneous breathing during gas ventilation (GV) and partial liquid ventilation (PLV) in cats with healthy and lavaged lungs.” Pediatric Academic Societies’ Annual Meeting, Seattle, USA, May 3-6, 2003. Pediatr Res. 53(4): 503 (abstract), 2003
7.    Rieger Fackeldey E, Sindelar R, Jonzon, A, and G Sedin.“Die Aktivität pulmonaler Dehnungsrezeptoren bei partieller Flüssigkeitsbeatmung von lungengesunden Katzen.“ 29. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin in Köln, July 3-5, 2003. Z. Geburtsh. Neonatol. 207: S2, 2003
8.    Rieger Fackeldey E, Sindelar R, Jonzon, A, and G Sedin.“Afferent vagal nerve activity plays a major role in regulation of breathing in surfactant-depleted cats.” Pediatric Academic Societies’ Annual Meeting, San Francisco, USA, May 1-4, 2004. Pediatr Res. 54(4): 555A (abstract), 2004
9.    Sindelar R, Rieger Fackeldey E, Jonzon, A, and G Sedin.“Afferent Vagal Nerve Activity Plays a Major Role in the Regulation of Breathing in Surfactant-depleted and Surfactant-instilled Cats.” Midnight Sun School on Perinatal Cardiorespiratory Adaptation, Turku, June 10-12, 2005
10.    Sindelar R, Rieger Fackeldey E, Jonzon, A, and G Sedin.“Inhibition of breathing after surfactant depletion is achieved at a higher arterial PCO2 during ventilation with liquid than with gas” Midnight Sun School on Perinatal Cardiorespiratory Adaptation, Turku, June 10-12, 2005
11.    Rieger Fackeldey E, Sindelar R, Jonzon, A, and G Sedin.“Pulmonary mechano-receptors strongly affect the breathing pattern in surfactant-depleted animals.” 32. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin in Vienna, May 18-20, 2006.  Z Geburtsh Neonatol 210: S16 (abstract), 2006
12.    Rieger Fackeldey E, Sindelar R, Jonzon, A, and G Sedin.“Partial liquid ventilation distends small airways in a similar way as gas ventilation: a study of pulmonary stretch receptor activity during different pressure waveforms.” 32. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin in Vienna, May 18-20, 2006. Z Geburtsh Neonatol 210: S70 (abstract), 2006
13.    Sindelar R, Rieger Fackeldey E, Jonzon A, Schaller, Schulze A, and G Sedin.“Maintained inspiratory activity during proportional assist ventilation early after surfactant instillation.” Pediatric Academic Societies’ Annual Meeting, San Francisco, April 29-May 2, 2006. Pediatr Res E-PAS2006:59:4830.93 (abstract), 2006
14.    Rieger Fackeldey E, Sindelar R, Jonzon, A, and G Sedin.“Pulmonary Mechano-Receptors Strongly Affect the Breathing Pattern in Surfactant-Depleted Animals” Pediatric Academic Societies’ Annual Meeting, San Francisco, April 29-May 2, 2006. Pediatr Res E-PAS2006:59:4830.91 (abstract), 2006
15.    Rieger Fackeldey E, Sindelar R, Jonzon, A, and G Sedin.“Partial Liquid Ventilation Distends Small Airways in a Similar Way as Gas Ventilation: A Study of Pulmonary Stretch Receptor Activity During Different Pressure Waveforms” Pediatric Academic Societies’ Annual Meeting, San Francisco, April 29-May 2, 2006. Pediatr Res E-PAS2006:59:5560.347 (abstract), 2006
16.    Sindelar R, Sedin G, and Jonzon A. “Pulmonary stretch receptor activity related to the energy storage of normal and surfactant-depleted lungs during spontaneous breathing” Europediatrics and European Society of Pediatric Research Annual Meeting in Barcelona, Spain, October 7-10, 2006. Eur J Ped 165: 431A (abstract), 2006
17.    Sindelar R, Jonzon A, and G Sedin. ”Bronchopulmonary C fibers complement pulmonary stretch receptors in modulating the breathing pattern in surfactant-depleted cats” International Perinatal Collegium, Grand Hotel in Saltsjöbaden, Stockholm, Sweden, July 13-17, 2007
18.    Sindelar R, and AH Jobe. “Lung interstitial white blood cell accumulation after ventilation of premature lambs exposed to intra-amniotic endotoxin” European Society of Pediatric Research Annual Meeting in Prague, Czech Republic, October 6-9, 2007. Acta Paediatr 96(s456): 212-213 (abstract), 2007
19.    Wallström L, Jonzon A, Schulze A, Sedin G, and R Sindelar. ”Proportional assist ventilation (PAV) - A mode of weaning from assist control   ventilation (A/C) to continuous positive airway pressure (CPAP)?” European Academy of Pediatrics and European Society of Pediatric Research Annual Meeting in Nice, France, October 24-28, 2008. Acta Paediatr : (abstract), 2008
20.    Wallström L, Jonzon A, Schulze A, Sedin G, and R Sindelar. ”Proportional Assist Ventilation (PAV) - A Mode of Weaning from Assist Control Ventilation (A/C) to Continuous Positive Airway Pressure (CPAP)?” Pediatric Academic Societies’ Annual Meeting in Baltimore, Maryland, May 2-5, 2009. Pediatr Res E-PAS2009 (abstract)
21.    Munsters JMA, Wallstrom L, Ågren J and R Sindelar. “Skin Conductance (SC) Measurements as Pain Assessment in Newborn Infants Born at 22-27 Gestational Weeks (GW) and at Different Postnatal Age (PNA)” Pediatric Academic Societies’ Annual Meeting in Baltimore, Maryland, May 2-5, 2009. Pediatr Res E-PAS2009 (abstract)
22.    Josanne Munsters, Ågren J, and R Sindelar. ”Skin Conductance (SC) measurements as pain assessment in newborn infants born at 22-27 postmenstrual age (PMA) at different postnatal age (PNA)” The Uppsala-Turku Perinatal Meeting, Tällberg, 17-19 September, 2009
23.    Karl Wilhelm Olsson, Jonzon A, and R Sindelar. ”Predictors for outcome of ductus arteriosus treatment and implications for future studies of pulmonary circulation” The Uppsala-Turku Perinatal Meeting, Tällberg, 17-19 September, 2009
24.    Maria Stålhammar, Douhan Håkansson L, and R Sindelar. ”In vitro studies of competetive chemotaxis and function of white blood cells from newborn infants - a model for modulating the development of chronic lung disease” The Uppsala-Turku Perinatal Meeting, Tällberg, 17-19 September, 2009
25.    Sindelar R, Wallström L, and A Jonzon. “Proportional assist ventilation (PAV) - a mode of weaning from assist control ventilation (A/C) to continuous positive airway pressure (CPAP)?” The Uppsala-Turku Perinatal Meeting, Tällberg, 17-19 September, 2009
26.    Olsson KW, Jonzon A, and R Sindelar. “Low ductal peak flow velocity prior to pharmacological treatment of patent ductus arteriosus predicts treatment failure in extremely preterm infants” Pediatric Academic Societies’ Annual Meeting in Vancouver, Canada, May 1-4, 2010. Pediatr Res E-PAS2010 (abstract)
27.    Stålhammar M, Douhan Håkansson L, and R Sindelar. “Under agarose migration assay – a method to study graded chemotactic acitivity of leukocytes in newborn infants” European Academy of Pediatrics and European Society of Pediatric Research Annual Meeting in Copenhagen, Denmark, October 22-26, 2010. Pediatr Res E-EAPS (abstract)
28.    Olsson KW and R Sindelar. ”Pharmacological ductus arteriosus treatment in infants born at 22-23 gestational weeks" ESPR, Newcastle, United Kingdom, 2011. Pediatr Res E-EAPS (abstract)
29.    Winderud M, Nilsson P, Jonzon A and R Sindelar. ”Diaphragm Pacing (DP) in congenital central hypoventilation syndrome (CCHS) – The Swedish experience” Science & Life of CHS, 4th International Conference on Primary Central Hypoventilation, Warsaw, Poland, April 13-15, 2012
30.    Winderud M, Jonzon A, Nilsson P, Mattsson E, and R Sindelar. “Living with Diaphragm Pacing. A Multinational Quality of Life (QoL) Study of Children with Congenital Central Hypoventilation Syndrome (CCHS) Using a Phrenic Nerve Stimulator” Science & Life of CHS, 4th International Conference on Primary Central Hypoventilation, Warsaw, Poland, April 13-15, 2012
31.    Stålhammar M, Sindelar R, and L Douhan Håkansson. ”Neutrophil Receptor Response to fMLP is Similar in Newborn Infants and Adults in Contrast to IL-8” European Society for Paediatric Infectious Diseases, Thessaloniki, Greece, May 9-12, 2012. Ped Inf Dis J E-ESPID (abstract)
32.    Munsters JMA and R Sindelar. “Skin conductance measurements as pain assessment during eye examinations for retinopathy of prematurity” 6th Nordic Congress of Pediatric Pain, Reykjavik, Iceland, Septembre 5-7, 2012
33.    Veneroni C, Wallström L, Dellaca R, and R Sindelar. ”Optimal PEEP in the first week of life in mechanically ventilated extremely preterm newborn infants: clinical setting vs. optimisation by Forced Oscillation Technique” European Respiratory Society, Vienna, Austria, Septembre 1-5, 2012. Eur J Resp E-ERS (abstract)
34.    Veneroni C, Wallström L, Zannin E, Dellacà R, and R Sindelar. ”Lung mechanics during the first week of life in ELGA newborn infants” Pediatric Academic Societies’ Annual Meeting in Vancouver, Canada, May 1-4, 2014. Pediatr Res E-PAS2014 (abstract)
35.    Olsson KW, Jonzon A, and R Sindelar. “Early circulatory and respiratory parameters in extremely preterm infants” 1st Congress of joint European Neonatal Societies (jENS) in Budapest, Hungary, September 16-20, 2015 Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) E-jENS2015 (abstract)
36.    Munsters JMA, Dovland Andersen R, Vederhus BJ, Sindelar R, and M Gradin. “The use of structured pain assessment methods in Swedish and Norwegian neonatal care units”. 10th International Forum on Pediatric Pain in White Point Beach Resort, Nova Scotia, October 1 – 4, 2015.
37.    Munsters JMA, Holmström G, and R Sindelar. “Skin conductance measurement as pain assessment during eye examinations for retinopathy of prematurity“. 10th International Forum on Pediatric Pain in White Point Beach Resort, Nova Scotia, October 1 – 4, 2015.
38.    Frid I, Ågren J, Normann E, and R Sindelar. “Safe Airborne Transports of Critically Ill Neonates – Is It Possible? Quality Survey of a regional cohort of Acute Neonatal Airborne Transports in Sweden 2012-2015“. 2nd Edition Transport of High Risk Neonates, Copenhagen, September 1-3, 2016
39.    Ågren J, and R Sindelar. “The impact of two levels of fluid volume allowance on weight change, plasma sodium, and selected outcomes in extremely preterm infants”. Pediatric Academic Societies’ Annual Meeting in Baltimore, USA, May 1-4, 2016. Pediatr Res E-PAS2016 (abstract)
40.    Markasz L, Sedin G, Savani RC,  and R Sindelar. “Hyaluronan receptor (RHAMM) expression in bronchiolar epithelium of neonates negatively correlates with air content in the lung”. 2nd Congress of joint European Neonatal Societies (jENS) in Venice, Italy, October 31-November 4, 2017. Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) 2017;6(2):e060236. doi: 10.7363/060236, p.34-35, E-jENS2017 (abstract)
41.    Olsson KW, and R Sindelar. “Early biochemical markers associated with development of necrotizing enterocolitis”. 2nd Congress of joint European Neonatal Societies (jENS) in Venice, Italy, October 31-November 4, 2017. Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) 2017;6(2):e060244. doi: 10.7363/060244, p.6-7, E-jENS2017 (abstract)
42.    Söderberg F, Holmström G, Larsson E, Ahlsson F, Normann E, Sindelar R, and J Ågren. "Reduced incidence of retinopathy of prematurity with intact survival after implementing lower oxygen saturation targets", Pediatric Academic Societies’ Annual Meeting in Toronto, Canada, May 5-8, 2018. Pediatr Res E-PAS2018 (abstract)
43.    McKinney RL, Keszler M, Truog W, Sindelar R, Schulman B, Gien J, Abman SH on behalf of the Bronchopulmonary Dysplasia Collaborative "Multicenter experience with neurally adjusted ventilatory assist in infants with evolving or established bronchopulmonary dysplasia", Pediatric Academic Societies’ Annual Meeting in Toronto, Canada, May 5-8, 2018. Pediatr Res E-PAS2018 (abstract)
44.    Jonzon A, Nilsson, and R Sindelar. “Phrenic nerve stimulation – a way to a more independent life for otherwise ventilator dependent individuals?” 5th CCHS International Research Conference in St. Louis, USA, June 20-23, 2018.
45.    Olsson KW, Youssef S, Kjellberg M, Raaijmakers R and R Sindelar. “A matched cohort study of surgical and non-surgical treatment for patent ductus arteriosus in extremely preterm infants” Pediatric Academic Societies’ Annual Meeting in Baltimore, USA, April 27-30, 2019. Pediatr Res E-PAS2019 (abstract)
46.    Olsson KW, Youssef S, Kjellberg M, Raaijmakers R and R Sindelar. “A matched cohort study of surgically treated patent ductus arteriosus in extremely preterm infants” Joint European Neonatal Societies Meeting in Maastricht, Belgium, September 17-20, 2019. Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) E-jENS201p (abstract)
47.    Markasz L, Savani RC, Jonzon A, and R Sindelar. “CD44 correlated to RHAMM expression in the human developing lung may be dependent on the gestational age” Joint European Neonatal Societies Meeting in Maastricht, Belgium, September 17-20, 2019. Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) E-jENS201p (abstract)
48.    Wallström L, Sjöberg A, and R Sindelar. “Early volume guarantee ventilation in extremely preterm infants born at 22-25 weeks of gestational age” European Academy of Pediatric Societies Biannual Meeting in Barcelona, 16-19 Octobre, 2020. Front Pediatr E-EAPS2020 (abstract)
49.    Hoffsten A, Markasz L, Ericson K, Nelin L, and R Sindelar. ”Causes of death and the value of autopsy in preterm infants at a tertiary neonatal intensive care unit 2002-2018” European Academy of Pediatric Societies Biannual Meeting in Barcelona, 16-19 Octobre, 2020. Front Pediatr E-EAPS2020 (abstract)
50.    Ågren J, and R Sindelar. “Fluid balance, weight change, and sodium homeostasis in infants born at 22-23 weeks of gestation”  Pediatric Academic Societies’ Annual Meeting in Philadelphia, USA, May 1-5, 2020. Pediatr Res E-PAS2020:632 (abstract)
51.    McKinney RL, Napolitano N, Matlock D, Lai K, Levin J, Leeman K, Baker CD, Hannan KE, Courtney S, Agarwal A, Kielt M, Shepherd E, Cuevas Guaman M, Truog W, McGrath-Morrow S, Collaco M, Sanlorenzo L, Sindelar R, Cristea I, Rose R, Eldredge L, Nelin L, and M Keszler, on behalf of BPD Collaborative. “Point Prevalence of Ventilatory Support in Children with Severe Bronchopulmonary Dysplasia” Pediatric Academic Societies’ Annual Meeting in Philadelphia, USA, May 1-5, 2020. Pediatr Res E-PAS2020 (abstract)
52.    Söderström F, Sindelar R, and J Ågren. “Earlier extubation attempt results in shorter duration of mechanical ventilation and lower incidence of severe BPD in extremely preterm infants” Pediatric Academic Societies’ Annual Meeting in Philadelphia, USA, May 1-5, 2020. Pediatr Res E-PAS2020 (abstract)
53.    Prusakov P, Wozniak P, Goff DA, Sanchez P, et al. “A Global Point Prevalence Survey of Antimicrobial Use in the Neonatal Intensive Care Unit (NICU): The NO-MAS-R Study” Pediatric Academic Societies’ Annual Meeting in Philadelphia, USA, May 1-5, 2020. Pediatr Res E-PAS2020:790 (abstract)
54.    Kielt MJ, Hatch D, Levin JC,Napolitano N, Baker CD, Eldredge LC, McGrath-Morrow SA, Collaco JM, Abman SH, Lain K, Rose RS, Matlock D, Lai K, Keszler M, Sindelar R, Nelin L, and RL McKinney, on behalf of BPD Collaborative.”Classifying Multi-center Ventilation Strategies for Severe Bronchopulmonary Dysplasia by Hierarchical Clustering Analysis”. Pediatric Academic Societies’ Annual Meeting in Denver, USA, April 21-25, 2022. Pediatr Res E-PAS2022 (abstract)  

 

 

 

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