Prof. Dr. Josef Neu

University of Florida, College of Medicine

CV

EDUCATION:
 
1971 Bachelor of Arts, Wisconsin State University, Whitewater, WI,
1975 Medical Doctorate, University of Wisconsin, Madison, WI,
1975-1978 Resident in Pediatrics, Johns Hopkins Hospital, Baltimore, MD,
1978-1980 Postdoctoral Fellow in Neonatology, Stanford University Medical Center, Stanford, CA, 1978-1980
1987  Sabbatical, Inselspital, University of Bern, Switzerland, 1987
Laboratory research with Dr. Michael Lentze on post- transcriptional lactase processing.
 
LICENSURE:
California-1978-1980
Wisconsin-1980-1984
Florida-1984-present #ME0044186
 
APPOINTMENTS:
Assistant Professor, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, 1980-1984
Director, Division of Neonatology, Milwaukee Children's Hospital, Milwaukee, WI, 1980-1984
Attending Physician, Pediatric Intensive Care Unit, Milwaukee Children's Hospital, Milwaukee, WI, 1980-1984
Associate Professor (tenured), Department of Pediatrics, Division of Neonatology, University of Florida, Gainesville, FL, 1984- 1993
Associate Division Chief, Department of Pediatrics, Division of Neonatology, University of Florida, Gainesville, FL, 1984-1994
Co-Director, Pediatric Intensive Care Unit, University of Florida, Gainesville, FL, 1984-1989
Director, Neonatology Fellowship Program, Department of Pediatrics, Division of Neonatology, University of Florida, Gainesville, FL, 1986-2020
Director, Neonatal Intensive Care Unit and Interim Division Chief, Department of Pediatrics, Division of Neonatology, University of Florida, Gainesville, FL, 1990-1991
Professor, Department of Pediatrics, Division of Neonatology, University of Florida, Gainesville, FL, 1993-present
 
NATIONAL and INTERNATIONAL COMMITTEES:
Elected to Council of the Organization of Neonatal Training Program Directors (2004-2010).
 
Chairman Organization of Neonatal Training Program Directors (Oct. 2007-2010)
 
Council of Pediatric Subspecialties (2008-1010). Served on Common Curriculum for Subspecialist Training and Common Matching Program Task Forces.
 
Chairperson of the Board of Directors: IPOKRaTES International: http://ipokrates.org/ since August 2011.
 
United States Member of International Consortium for Health Outcomes Measurement for Neonatology since 2018.  

PUBLICATIONS

Publications

Books
 
1. Hamilton LH, Neu J, Calkins J (eds).  High Frequency Ventilation.  CRC Press, 1986.
2. Koff P, Eitzman D, Neu J (eds).  Neonatal and Pediatric Respiratory Care.  C.V. Mosby, 1988.
3. Koff P, Eitzman D, Neu J (eds).  Neonatal and Pediatric Respiratory Care, Second Edition. C.V. Mosby, 1993.
4. Neu, J. (editor). Neonatal Gastroenterology and Nutrition (Elsevier Press) 2008.
5. Fanaroff, AA., Benitz, W., Neu, J., Papile, L.A. Year Book of Neonatal and Perinatal Medicine, 2009.
6. Fanaroff, AA., Benitz, WE., Donn, SM, Neu J., Papile LA. Year Book of Neonatal and Perinatal Medicine, 2010, 2011,2012,2013,2014,2016,2016.
7. Neu, J. (editor). Neonatal Gastroenterology and Nutrition 2nd Edition. 2012.
8. Brodsky, D., Neu J. (co-editors): Challenging Cases in Neonatology. 2018.  
9. Poindexter, B., Neu J. (Co-editors) Controversies in Neonatal Gastroenterology and Nutrition. (2018).
10. Neu, J. (Monograph) The Microbiome in Prenatal and Neonatal Life---Published Jan 15,2021.
11. The Science of Human Milk----In Preparation
 
Chapters in Books:
 
1. Neu J: Procedures. In: Schubert K and Zitelli B (eds). The Harriet Lane Handbook for Pediatric House Officers, Eighth Edition. Year Book Medical Publishers, 1978.
2. Neu J: Gastrointestinal problems and nutrition in neonatal and pediatric intensive care. In: Vidyasagar D and Sarnaik AP (eds). Neonatal and Pediatric Critical Care, Chapter 23. PSG Publishing Company, pp.284-312, 1985.
3. Hagen EA, Bucciarelli RL, Neu J: Hemodynamic effects of high frequency ventilation. In: Hamilton LH, Neu J, Calkins J (eds). High Frequency Ventilation. CRC Press, pp. 61-72, 1986.
4. Burchfield DJ, Neu J: Neonatal parenchymal problems. In: Koff P, Eitzman DV, Neu J (eds). Neonatal and Pediatric Respiratory Care. C.V. Mosby, 1988.
5. Polak MJ, Neu J: Novel modalities of providing respiratory support. In: Koff P, Eitzman DV, Neu J (eds). Neonatal and Pediatric Respiratory Care. C.V. Mosby, 1988.
6. Neu J, Wu-Wang CY: Eicosanoids in human milk. In: Lands W (ed). Proceedings of the AOCS, Short Course on Polyunsaturated Fatty Acids and Eicosanoids, pp. 523-528, 1987.
7. Neu J: Necrotizing enterocolitis. Rudolph's Textbook of Pediatrics, Nineteenth Edition, 1991.
8. Burchfield DJ, Neu J: Neonatal parenchymal diseases. In: Koff P, Eitzman DV, Neu J (eds). Neonatal and Pediatric Respiratory Care, Second Edition. C.V. Mosby, pp. 75-91, 1993.
9. Neu J: Early Enteral Feedings for extremely low birthweight and very low birthweight infants. Seminars in Neonatal Nutrition and Metabolism, Vol 7, No. 1, 2000.
10. Weiss MD, Ledbetter DJ, Neu J: Necrotizing enterocolitis.  In: Polin RA and Yoder MC (eds). Workbook in Practical Neonatology, Third Edition, 2000.
 
11. Neu J: Feeding strategies of the premature/sick infant. In: Lifshitz C. Pediatric
Gastroenterology and Nutrition in Clinical Practice, Marcel
  Dekker, Inc., pp. 203- 222, 2002
12. Brown R, Neu J. Necrotizing Enterocolitis. In: Poland R.Textbook of Neonatology.
13. Neu J. Neonatal and Infant Microflora. In Probiotics in Pediatric Medicine, Edited by Sonia Michail and Philip Sherman Humana Press, 2009
14. Neu J and Douglas Escobar M. Neonatal GI Development and feeding strategies. Neonatal Nutrition. Edited by W.A. Walker.2010
15. Neu J. and Mshvildadze M. Development of the GI tract. In Fox, Polin and Abman. Physiology of the Neonate. 2011.
16. Neu J, Lorca G, Kingma, S.D.K., Triplett, E. The Intestinal Microbiome: Relationship to Type 1 Diabetes. Endocrinology and Metabolism Clinics of North America. Vol 39, Number 3, pp. 563-571;Sept. 2010
17. Young, C., Mai V., Neu J. Chapter 71. The Intestinal Microbiome in the Neonate. AVERY‘S DISEASES OF THE NEWBORN, 2011.
18. Neu J. Overview of Digestion and Absorption. Chapter 1. Neonatology Questions and Controversies. Gastroenterology and Nutrition. 2nd edition, 2012.
19. Neu J. and Mai, V. The Developing Intestinal Microbiomne and Its Relationship tp Health and Disease. Chapter 5. Neonatology Questions and Controversies. Gastroenterology and Nutrition. 2nd edition, 2012.
20. Neu J. What are the Controversies for Basic Intestinal Development and Where Will the Field Be Moving in the Future? Chapter 8. Neonatology Questions and Controversies. Gastroenterology and Nutrition. 2nd edition, 2012.
21. Neu J. Nutritional Requirements for the Neonate: What are the Controversies and Where Will the Field be Moving in the Future? Chapter 14. Neonatology Questions and Controversies. Gastroenterology and Nutrition. 2nd edition, 2012.
22. Sharma, R., Young, C., Neu J. Necrotizing Enterocolits. Chapter 15.
Neonatology Questions and Controversies. Gastroenterology and Nutrition. 2nd edition, 2012.
23. Wynn, J.L.and Neu, J. The Neonatal Gastrointestinal Tract as a Conduit to
Systemic Inflammation and Developmental Delays. Chapter 19. Neonatology
Questions and Controversies. Gastroenterology and Nutrition. 2nd edition, 2012.
24. Oh, Sungho, Kim, EK, Neu J., Technologies for the Evaluation of Enteral Feeding Readiness in Premature Infants. Chapter 21. Neonatology Questions and Controversies. Gastroenterology and Nutrition. 2nd edition, 2012.
25. What are the Controversies for these Clinical Conditions and Wherte Will the Field Be Moving in the Future? Chapter 22. Neonatology Questions and Controversies. Gastroenterology and Nutrition. 2nd edition, 2012.
26. Neu J, Young C., Mai V. The Developing Intestinal Microbiome: Implications for the Neonate. Gleason and Devaskar: Avery’s Diseases of the Newborn.
27. Neu J., Neonatal Necrotizing Enterocolitis. Probiotic Bacteria and Their Effect on Human Health and Well Being. Editors, A. Guarino, EMM Quigley, WA Walker. Vol 107, 2013.
28. Neu J., The Developing Intestinal Microbiome: Probiotics and Prebiotics.
Nutritional Care of Preterm Infants. Editor B. Koletzko,B. Poindexter and R. Uauy. 2013.
29. Neu J., Necrotizing Enterocolitis. Nutritional Care of Preterm Infants. Editor B. Koletzko,B. Poindexter and R. Uauy. 2013.
30. Ortigoza, E. Neu, J. Necrotizing Enterocolitis. Ch. 22. Workbook in Practical Neonatology. Editors R. Polin and M. Yoder. 5th Edition, 2015.
31. Dela Cruz, D. and Neu J., Relationship of Probiotics, Prebiotics, Synbiotics to Infections, Immunity, and Nutrition. Ch. 12 in Nutrition—Infection Interactions and Impacts on Human Health. Edited by Pammi,M., Ballejo, JG, and Abrams, Aug. 2014.
32. Kudin, O. and Neu, J. Necrotizing Enterocolitis in Fanaroff & Martin’s Neonatal-Perinatal Medicine, 2018.
33. Bajorek S., Neu J. Necrotizing Enterocolitis. For Neonatology - A Practical
Approach to Neonatal Diseases edited by Giuseppe Bounocore. 2018.
 
Currently have 8 chapters that are in print---not yet published.
 
REFEREED ORIGINAL RESEACH ARTICLES
 
1. Prober CG, Stevenson DK, Neu J, Johnson JD: The white cell ratio in the very low birthweight infant and prolonged rupture of membranes in full term infants. Clin Pediatr 18(8):481-486, 1979.
2. Neu J, Arvin AM, Ariagno RL: Hydrops of the gallbladder in a neonate associated with group b-beta streptococcus, sepsis and pneumonia. Am J Dis Child 134(9):891-893, 1980.
3. Stevenson DK, Hsu Y-P, McMorrow M, Berseth CL, Neu J, Miller JJ, III: Complement concentrations and activation of the complement system in neonatal illness: A preliminary study of necrotizing enterocolitis. Eur J Pediatr 134(3):2255-2259, 1980.
4. Tsuboi KK, Kwong LK, Neu J, Sunshine P: A proposed mechanism of normal intestinal lactase decline in the postweaned mammal. Biochem Biophys Res Com 101(2):645-652, 1981.
5. Neu J, Ariagno RL, Johnson JD, Pitlick PT, Cohen RS, Beets CL, Sunshine P: A double blind study of the effects of oral indomethacin in preterm infants with patent ductus arteriosus who failed medical management. Pediatr Pharmacol 1(3):245-249, 1981.
6. Neu J, Masi M, Stevenson DK, Kwong LK, Hurwitz R, Sunshine P: The effect of asphyxia and oral gentamicin on intestinal lactase in the suckling rat. Pediatr Pharmacol 1(3):215-220, 1981.
7. Ostrander CR, Stevenson DK, Neu J, Moses SW: A sensitive analytical apparatus for measuring hydrogen production rate. 1. The application to studies in small animals. Evidence for the effects of an alpha-glucoside hydrolase inhibitor in the rat. Anal Biochem 119(2):378-386, 1982.
8. Neu J, Mahoney C, Wilson AD, Rice TB: Calculator assisted determination of dilutions for continuous infusion ICU medications. Crit Care Med 10(9):610-612, 1982.
9. Neu J, Crim WN, Kien CL, Kelly K: Calculator assisted monitoring of nutrition, fluids and electrolytes. Crit Care Med 10(7):461-462, 1982.
10. Neu J, Hoffmann RG, Crim WN: Prostaglandin-mediated effects on growth and markers of biochemical development in the rat. Pediatr Res 17:537-540, 1983.
11. Neu J, Crim WN, Sadowski JA: Comparison of detergent versus protease solubilized rat intestinal lactase. Enzyme 32:133-141, 1984.
12. Kelly KJ, Neu J, Camitta BM, Honig GR: Methemoglobinemia in an infant treated with the folk remedy ―Glycerited Asafoetida‖. Pediatrics 73(5):717-719, May, 1984.
13. Kelly KJ, Neu J, Rice TB, Crim WN, Eisenberg C: Efficacy of a programmed calculator for constant-infusion medication calculations. Pediatrics 73(1):68-70, January, 1984.
14. Neu J, Hamilton LH, Linehan JH: Long-term high-frequency jet ventilation in neonates. Crit Care Med 12(9):833-835, 1984.
15. Hamilton LH, Londino JM, Linehan JH, Neu J: A pediatric endotracheal tube designed for high-frequency ventilation. Crit Care Med 12(11):988-993, 1984.
16. Garland JS, Nelson DB, Rice TB, Neu J: Increased risk of gastrointestinal perforation in neonates mechanically ventilated with either face mask or nasal prongs. Pediatrics 76(3):406-420, 1985.
17. Neu J, Ozaki CK, Angelides KJ: Glucocorticoid-mediated alteration of fluidity of brush-border membrane in rat small intestine. Pediatr Res 20(1):79-82, 1986.
18. Neu J, Crim WN, Hodge NC: Comparative effects of glucocorticoids and prostaglandins on small intestine of infant rats. Pediatr Res 20(2):109-112, 1986.
19. Carr DJ, Rich M, Murkowski K, Neu J: A comparative evaluation of three neonatal ventilators. Crit Care Med 14(6):234-236, 1986.
20. Wu-Wang CY, Neu J: Low levels of prostaglandins in human milk after purification by high performance liquid chromatography. Prostag Leukotr Ess 24:207-218, 1986.
21. Wu-Wang CY, Neu J: Microsomal arachidonate bioconversion in rat small intestine during maturation. Prostag Leukotr Ess 27(1):71-80, 1987.
22. Engelhardt EL, Beggs JC, Neu J: Maturation of antioxidant enzymes in rat small intestine: Lack of glucocorticoid stimulation. J Pediatr 111(3):459-463, 1987.
23. Neu J, Walker WR, Engelhardt EL, Wu-Wang CY, Rao MB, Gimotty PA: Alterations in piglet small intestine after cholesterol deprivation. Pediatr Res 22(3):330-334, 1987.
24. Neu J, Wu-Wang CY, Measel CP, Gimotty PA: Low concentrations of prostaglandins in human milk. Am J Clin Nutr 47:649-652, 1988.
25. Espejo MG, Neu J, Hamilton LH, Eitzman B, Gimotty PA, Bucciarelli RL: Determination of extracellular fluid volume using impedance measurements. Crit Care Med 17(4):360-363, 1989.
26. Wu-Wang CY, Wang SL, Stevens B, Neu J: Localization and characterization of prostaglandin E1 receptors in rat small intestine. Prostag Leukotr Ess 36(3):129- 134, 1989.
27. Engelhardt EL, Neu J, Sankar MB, Gimotty PA, Meyer JW: Changes in phospholipid and cholesterol concentrations of rat microvillus membrane during maturation. J Pediatr Gastr Nutr 9:89-93, 1989.
28. Covert RF, Neu J, Elliott MJ, Rea JL, Gimotty PA: Factors associated with age of onset of necrotizing enterocolitis. Am J Perinatol 6(4):455-460, 1989.
29. Neu J, Wu-Wang CY: Ontogeny of PGE1 receptor binding in rat small intestine. Prostag Leukotr Ess 41(1):63-66, 1990.
30. Engelhardt EL, Sankar MB, Wu-Wang CY, Thomas MR, Walker WR, Neu J: Effect of cholesterol deprivation on piglet small intestine and serum lipoprotein profile. J Pediatr Gastr Nutr 12:494-500, 1991.
31. Meetze WH, Valentine C, McGuigan JE, Conlon M, Sacks N, Neu J: Gastrointestinal priming prior to full enteral nutrition in very low birthweight neonates. J Pediatr Gastr Nutr 15:163-170, 1992.
32. Meetze WH, Shenoy V, Martin G, Musy P, Neu J: Ontogeny of small intestinal glutaminase and glutamine synthetase in the rat: Response to dexamethasone. Biol Neonate 64:368-375, 1993.
33. Meetze WH, Palazzolo V, Burchfield DJ, Behnke M, Neu J: Meconium passage in the micropremie: Effect of hypocaloric enteral priming. JPEN 17:537-540, 1993.
34. Roig JC, Shenoy V, Chakrabarti R, Lau JYN, Neu J: Localization of rat small intestinal glutamine synthetase using immunofluorescence and in situ hybridization. JPEN 19:179-181, 1995.
35. Shenoy V, Roig JC, Chakrabarti R, Kubilis P, Neu J: Ontogeny of glutamine synthetase in rat small intestine. Pediatr Res 39(4):643-648, 1996.
36. Shenoy V, Roig JC, Kubilis P, Neu J: Characterization of glutaminase in the developing rat small intestine. J Nutr 126:1121S-1130S, 1996.
37. Roig JC, Meetze WH, Auestad N, Jasionowksi T, Veerman M, McMurray CA, Neu J: Enteral glutamine supplementation for the very low birthweight infant: Plasma amino acid concentrations. J Nutr 126:1115S-1120S, 1996.
38. Darmaun D, Roig JC, Auestad N, Neu J: Glutamine metabolism in very low birthweight infants. Pediatr Res 41(3):391-396, 1997.
39. DeMarco VG, McCain M, Strauss DM, Shenoy V, Chakrabarti R, Neu J: Characterization of glutamine synthetase transcript, protein and enzyme activity in the human placenta. Placenta 18(7):541-545, 1997.
40. Neu J, Roig JC, Meetze WH, Veerman M, Carter C, Millsaps MM, Bowling D, Dallas MJ, Auestad N: Enteral glutamine supplementation for very low birthweight infants decrease morbidity. J Pediatr 131(5):691-699, 1997.
41. DeMarco VG, Dyess K, Strauss DM, West CM, Neu J: Inhibition of glutamine synthetase decreased cell proliferation of cultured rat intestinal epithelial cells. J Nutr 129(1):57-62, 1998.
42. Dallas MJ, Bowling D, Roig JC, Auestad N, Neu J: Enteral glutamine supplementation for very low birthweight infants decreases hospital costs. JPEN 22(6):352-6, 1998.
43. Weiss MD, DeMarco VG, Strauss DM, Samuelson DA, Lane ME, Neu J:
Glutamine synthetase: A key enzyme for intestinal epithelial differentiation? JPEN 23(3):140-146, 1999.
44. Potsic BJ, Neu J, DeMarco VG, Tremper K, Holliday N, Samuelson D, Lewis P: Glutamine deprivation: Effect on the small intestinal barrier. Pediatr Res 52(3):430-6, 2002.
45. Patel MR, DeMarco VG, Clare-Salzler M, Neu J: High dose indomethacin does not cause intestinal damage in infant rats: What is the mechanism? J Pediatr Gastr Nutr 35(2):154-61, 2002.
46. Li N, DeMarco VG, West CM, Neu J: Glutamine supports recovery from impedance reductions by media change in Caco-2 cells. J. Nutritional Biochemistry. 2003 Jul; 14(7):401-8.
47. DeMarco VG, Li N, West CM, Thomas J, Neu J: Characterization of glutamine requirements for the maintenance of barrier function in Caco-2 monolayers. J. Nutrition 2003 Jul; 133(7):2176-9.
48. Huang Y, Li N, Liboni K, Neu J: Glutamine decreases endotoxin- induced IL-8 production in Caco-2 cells via non-NF kappa-B pathways. Cytokine 2003 May; 22(3-4):77-83.
49. Vaughn P, Thomas P, Clark R, Neu, J: Enteral glutamine supplementation and morbidity in low birthweight infants. J. Pediatrics. 2003 Jun; 142(6):662-8.
50. Li N, Liboni K, Fang MZ, Samuelson D, Lewis P, Patel R, Neu J. Glutamine
Decreases Lipopolysaccharide-Induced Intestinal Inflammation in Infant Rats. Am J Physiol Gastrointest Liver Physiol. 2004 Jan 15 [Epub ahead of print].
51. Tuhacek LM, Mackey AD, DeMarco VG, Li N, Stevens G, Neu J: Are there
substitutes for glutamine in proliferation of rat intestinal epithelial cells? Nutrition.
2004 Mar; 20(3):292-7.
52. Liboni K, Li N, Neu J. Mechanism of glutamine-induced amelioration of lipopolysaccharide-induced IL-8 production in Caco-2 cells. Cytokine. 2004 Apr 21;26(2):57-65.
53. Li, N., Lassman, E., Liu, Z., Liboni, K., Neu. The Effects of Protein Deprivation on
Growth and Small Intestine Morphology Are Not Ameliorated By Glutamine or Glutamate in Gastrostomy-Fed Rat Pups. Journal of Pediatric Gastroenterology and Nutrition. 2004 Jul;39(1):28-33.
54. Li N, Lewis P, Samuelson D, Liboni K, Neu J. Glutamine Regulates Caco-2 Cell Tight Junction Proteins. Am J Physiol Gastrointest Liver Physiol. 2004 May 6 .
55. Beierle EA, Chen MK, Hartwich JE, Iyengar M, Dai W, Li N, Demarco V, Neu J.
Artificial Rearing of Mouse Pups: Development of a Mouse Pup in a Cup Model. Pediatr Res. 2004 Jun 4 [Epub ahead of print].
56. Liboni, K.C., Li N, Scumpia P.O., Neu J. Glutamine Modulates LPS-Induced IL-8 Production through IkB/NF-KB in Human Fetal and Adult Intestinal Epithelium.J.
of Nutrition. 2005 Feb; 135(2):245-51.
57. Zhang L, Li N, Caicedo R, Neu J. Lactobacillus Rhamnosus GG (LGG) Dead or Alive Decreases Tumor Necrosis Factor- Induced IL-8 Production in Caco-2 cells J Nutr. 2005 Jul;135(7):1752-6.
58. Josef Neu, Christopher M. Reverte, Amy D. Mackey, Kellym Liboni, Lauren M.
Tuhacek-Tenace, Marguerite Hatch, Nan Li, Ricardo A. Caicedo, Desmond A. Schatz, and Mark Atkinson Changes in Intestinal Morphology and Permeability in the Biobreeding(BB) Rat Prior to the Onset of Type 1 diabetes. J Pediatr Gastroenterol Nutr. 2005 May;40(5):589-95.
59. Liyan Zhang, M.D.* Nan Li, M.D., Kellym Liboni, M.D., Clotilde desRobert, M.D, Robert McMahon, Ph.D. **, Richard Caicedo, M.D., Josef Neu, M.D.
Lactobacillus Rhamnosus GG (LGG) Decreases Lipopolysaccharide (LPS)- Induced Systemic Inflammation In A Gastrostomy-Fed Infant Rat Model J Pediatr Gastroenterol Nutr. 2006 May;42(5):545-552.
60. Neu J, Ajzal A, Pan H, Gallego E, Li N, Calzi SL, Caballlero S, Spoerri PE, Shaw
LC, Grant MB. The Dipetptide Arg-GLN Inhibits Retinal Neovascularization I the
Mouse Model of Oxygen-Induced Retinotpathy. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3151-5
61. Caicedo RA, Li N, DES Robert C, Scumpia PO, Hubsher CP, Wasserfall CH,
Schatz DA, Atkinson MA, Neu J. Neonatal Formula Feeding Leads to
Immunological Alterations in an Animal Model of Type 1 Diabetes. Pediatr Res. 2008 Mar; 63(3):303-7.
62. des Robert C, Li N, Caicedo R., Frost S, Lane R. Hauser N. , Neu J. Metabolic Effects of Different Protein Intakes after Short Term Undernutrition in artificially reared Infant Rats.  Early Hum Dev. 2008 Jul 21.
63. Lopez, M.  Li, N. Kataria, J. Russell,M.  Neu, J.. Live and Ultraviolet-Inactivated Lactobacillus Rhamnosus GG Decreases Flagellin Induced Interleukin-8 Production in Caco-2 Cells J Nutr. 2008 Nov;138(11):2264-8.
64. Li N, Neu J. Glutamine Deprivation Alters Intestinal Tight Junctions via a PI3-K/Akt Mediated Pathway in Caco-2 Cells. J Nutr. 2009 Feb 11. [Epub ahead of print]
65. Roesch LF, Lorca GL, Casella G, Giongo A, Naranjo A, Pionzio AM, Li N, Mai V, Wasserfall CH, Schatz D, Atkinson MA, Neu J, Triplett EW. Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model. ISME J. 2009 Feb 19. [Epub ahead of print]
66. Luiz F. W. Roesch, George Casella, Olli Simell, Jeffrey Krischer, Clive H. Wasserfall, Desmond Schatz, Mark A. Atkinson, Josef Neu and Eric W. Triplett Influence of Fecal Sample Storage on Bacterial Community Diversity 2009 The Open Microbiology Journal, 2009, 3. Open Microbiol J. 2009;3:40-6. Epub 2009 Mar 24.
67. Li N, Russell WM, Douglas-Escobar M, Hauser N, Lopez M, Neu J. Live and Heat- killed Lactobacillus Rhamnosus GG (LGG): Effects on Pro and Anti- Inflammatory Cyto/Chemokines in Gastrostomy-Fed Infant Rats. Pediatr Res. 2009 Apr 22.
68. Mshvildadze, M. Neu, J. Shuster; J. Theriaque D. Li, N, Mai V. Intestinal Microbial Ecology in Premature Infants Using Non-Culture Based Techniques. Journal of Pediatrics 2009 Sep 25.
69. Li, N., Douglas-Escobar, M., Hatch, M., Atkinson, M., Schatz, D., Neu J. 'Butyrate and Type 1 Diabetes: Can We Fix the Intestinal Leak? Journal of Pediatric Gastroenterology and Nutrition: 2010 Oct;51(4):414-7.
70. Valladares R, Sankar D, Li N, Williams E, Lai KK, Abdelgeliel AS, Gonzalez CF, Wasserfall CH, Larkin J, Schatz D, Atkinson MA, Triplett EW, Neu J, Lorca GL. Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB- DP rats.PLoS One. 2010 May 6;5(5):e10507.
71. Giongo A, Gano KA, Crabb DB, Mukherjee N, Novelo LL, Casella G, Drew JC, Ilonen J, Knip M, Hyöty H, Veijola R, Simell T, Simell O, Neu J, Wasserfall CH, Schatz D, Atkinson MA, Triplett EW. Toward defining the autoimmune microbiome for type 1 Diabetes. ISME J. 2010 Jul 8.
72. Kenneth Lau, Patrick Benitez, Alexandria Ardissone, Tenisha D. Wilson, Erin L.
Collins,Graciela Lorca, Nan Li†, Dhyana Sankar, Clive Wasserfall, Josef Neu,
Mark A. Atkinson‡, Desmond Schatz†, Eric W. Triplett, and Joseph Larkin III*,
Inhibition of Type 1 Diabetes Correlated to a Lactobacillus johnsonii N6.2 Mediated Th17 Bias1. Journal of Immunology.  J Immunol. 2011 Mar 15;186(6):3538-46.
73. Kingma SD, Li N, Sun F, Valladares RB, Neu J, Lorca GL.  Lactobacillus johnsonii N6.2 Stimulates the Innate Immune Response through Toll-Like Receptor 9 in Caco-2 Cells and Increases Intestinal Crypt Paneth Cell Number in BioBreeding Diabetes-Prone Rats. J Nutr. 2011 Jun;141(6):1023-8.
74. Mai V, Young CM, Ukhanova M, Wang X, Sun Y, Casella G, Theriaque D, Li N, Sharma R, Hudak M, Neu J. Fecal microbiota in premature infants prior to necrotizing enterocolitis. PLoS One. 2011;6(6):e20647
75. Li N., Ma L., Liu X., Shaw L., Calzi S.,  Grant M. Neu J. Arginyl-Glutamine (Arg- Gln) Dipeptide or Docosahexaenoic Acid (DHA) Attenuate Hyperoxia-Induced Small Intestinal Injury in Neonatal Mice. Journal of Pediatric Gastroenterology and Nutrition, 2011 Oct 20.
76. Brown CT, Davis-Richardson AG, Giongo A, Gano KA, Crabb DB, Mukherjee N,
Casella G, Drew JC, Ilonen J, Knip M, Hyöty H, Veijola R, Simell T, Simell O, Neu J, Wasserfall CH, Schatz D, Atkinson MA, Triplett EW. Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS One. 2011;6(10):e25792. Epub 2011 Oct 17.
77. Ukhanova M, Culpepper T, Baer D, Gordon D, Kanahori S, Valentine J, Neu J, Sun Y, Wang X, Mai V.Gut microbiota correlates with energy gain from dietary fibre and appears to be associated with acute and chronic intestinal diseases. Clin Microbiol Infect. 2012 Jul;18 Suppl 4:62-6. doi: 10.1111/j.1469- 0691.2012.03859.x.
78. Ma, L., Li N., Liu X., Shaw L., Li Calzi. S., Grant, M., Neu J. Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal mice. Nutrition. 2012 Nov;28(11-12):1186-91.
79. Li N, Quidgley MC, Kobeissy FH, Joseph J, Neu J. Microbial cell components induced tolerance to flagellin-stimulated inflammation through Toll-like receptor pathways in intestinal epithelial cells. Cytokine. 2012 Aug 31.
80. Mai V, Torrazza RM, Ukhanova M, Wang X, Sun Y, Li N, Shuster J, Sharma R, Hudak ML, Neu J. Distortions in development of intestinal microbiota associated with late onset sepsis in preterm infants. PLoS One. 2013;8(1):e52876. doi:
10.1371/journal.pone.0052876.
81. Murgas Torrazza, R., Nan Li, Christopher Young, Firas Kobeissy, Marjorie Chow, Sixue Chen, Volker Mai, Renu Sharma, Mark Hudak, Jonathan Shuster and
Josef Neu. Pilot Study using proteomics to identify Predictive  Biomarkers for Necrotizing Enterocolitis from buccal swabs in very low birthweight premature infants. Early Diagnosis and Prediction of Necrotizing Enterocolitis in Very Low Birth Weight Infants. Neonatology. 2013;104(3):234-42..
82. Shuster, J.F., Neu J. A Pocock approach to sequential meta-analysis of clinical trials. Research Synthesis Methods. Research Synthesis Methods. 2013 Sep;4(3).
83. Torrazza RM, Ukhanova M, Wang X, Sharma R, Hudak ML, Neu J, Mai V. Intestinal microbial ecology and environmental factors affecting necrotizing enterocolitis. PLoS One 2013 Dec. 30;8(12).
84. Ardissone AN, de la Cruz DM, Davis-Richardson AG, Rechcigl, KT, Li N, Drew JC, Murgas-Torrazza R, Sharma R, Hudak ML, Triplett EW, Neu J. Meconium microbiome analysis identifies bacteria correlated with premature birth. PLoS One. 2014 Mar 10;9(3):e90784.
85. Sharma R, Kraemer DF, Torrazza RM, Mai V, Neu J, Shuster JJ, Hudak ML.
Packed red blood cell transfusion is not associated with increased risk of necrotizing enterocolitis in premature infants. J Perinatol. 2014 Nov;34(11):858-62
86. Torrazza RM, Parker LA, Li Y, Talaga E, Shuster J, Neu J. The value of routine evaluation of gastric residuals in very low birth weight infants. J Perinatol. 2014 Aug 28.
87. Raiten DJ, Steiber AL, Carlson SE, Griffin I, Anderson D, Hay WW Jr, Robins S,
Neu J, Georgieff MK, Groh-Wargo S, Fenton TR; Pre-B Consultative Working Groups. Working group reports: evaluation of the evidence to support practice guidelines for nutritional care of preterm infants-the Pre-B Project. Am J Clin Nutr. 2016 Feb;103(2):648S-78S.
88. Pammi M, Cope J, Tarr PI, Warner BB, Morrow AL, Mai V, Gregory KE, Kroll JS,
McMurtry V, Ferris MJ, Engstrand L, Lilja HE, Hollister EB, Versalovic J, Neu J.Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis. Microbiome. 2017 Mar 9;5(1):31. doi:
10.1186/s40168-017-0248-8.
89. Rozé JC, Ancel PY, Lepage P, Martin-Marchand L, Al Nabhani Z, Delannoy J,
Picaud JC, Lapillonne A, Aires J, Durox M, Darmaun D, Neu J, Butel MJ; Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants. Nutrition EPIPAGE 2 study group and the EPIFLORE Study Group.Am J Clin Nutr. 2017 Jun 28. pii: ajcn152967. doi:
10.3945/ajcn.117.152967. [Epub ahead of print] PMID: 28659297
90. Zarate MA, Rodriguez MD, Chang EI, Russell JT, Arndt TJ, Richards EM, Ocasio BA, Aranda E, Gordon EM, Yu K, Neu J, Keller-Wood M, Triplett EW, Wood CE. Posthypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus. Sci Rep. 2017 Jul 25;7(1):6458. doi: 10.1038/s41598-017-06789-6.
91. Cacho NT, Harrison NA, Parker LA, Padgett KA, Lemas DJ, Marcial GE, Li N, Carr LE, Neu J, Lorca GL.Personalization of the Microbiota of Donor Human Milk with Mother's Own Milk. Front Microbiol. 2017 Aug 3;8:1470. doi: 10.3389/fmicb.2017.01470.
92. Colliou N, Ge Y, Sahay B, Gong M, Zadeh M, Owen JL, Neu J, Farmerie WG, Alonzo F 3rd, Liu K, Jones DP, Li S, Mohamadzadeh M. Commensal Propionibacterium strain UF1 mitigates intestinal inflammation via Th17 cell regulation. J Clin Invest. 2017 Nov 1;127(11):3970-3986. doi: 10.1172/JCI95376.
93. Cortez J, Makker K, Kraemer DF, Neu J, Sharma R, Hudak ML.Maternal milk feedings reduce sepsis, necrotizing enterocolitis and improve outcomes of premature infants. J Perinatol. 2018 Jan;38(1):71-74. doi: 10.1038/jp.2017.149.
94. Ortigoza EB, Cagle J, Chien JH, Oh S, Brown LS, Neu J. Electrogastrography, Near-infrared Spectroscopy and Acoustics to Measure Gastrointestinal Development in Preterm Babies. J Pediatr Gastroenterol Nutr. 2017 Dec 28. doi: 10.1097/MPG.
95. Shaw LC, Li Calzi S, Li N, Moldovan L, Sengupta-Caballero N, Quigley JL, Ivan M, Jun B, Bazan NG, Boulton ME, Busik J, Neu J, Grant MB. Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity.Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):858-869. doi: 10.1167/iovs.17-23034
96. Chang LL, Wynn JL, Pacella MJ, Rossignol CC, Banadera F, Alviedo N, Vargas A, Bennett J, Huene M, Copenhaver N, Sura L, Barnette K, Solomon J, Bliznyuk NA. Neu J, Weiss MD. Enteral Feeding as an Adjunct to Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy. Neonatology. 2018 Mar 6;113(4):347-352. doi: 10.1159/000487848
97. Lenfestey, M.W., de la Cruz, D. Neu, J. Food Protein–Induced Enterocolitis Instead of Necrotizing Enterocolitis? A Neonatal Intensive Care Unit Case Series. J. Peds. 2018 Sep;200:270-273.
98. Bajorek S, Parker L, Li N, Winglee K, Weaver M, Johnson J, Sioda M, Gauthier J, Lemas DJ, Jobin C, Lorca G, Neu J, Fodor AA. Initial microbial community of the neonatal stomach immediately after birth. Gut Microbes. 2018 Nov 7:1-9.
99. Pope JL, Yang Y, Newsome RC, Sun W, Sun X, Ukhanova M, Neu J, Issa JP, Mai V, Jobin C. Microbial Colonization Coordinates the Pathogenesis of a Klebsiella pneumoniae Infant Isolate. Sci Rep. 2019 Mar 4;9(1):3380.
100. Parker LA, Weaver M, Murgas Torrazza RJ, Shuster J, Li N, Krueger C, Neu J. Effect of Gastric Residual Evaluation on Enteral Intake in Extremely Preterm Infants: A Randomized Clinical Trial. JAMA Pediatr. 2019 Apr 29.
101. Parker LA, Cacho N, Engelmann C, Benedict J, Wymer S, Michael W, Neu Consumption of Mother's Own Milk by Infants Born Extremely Preterm Following Implementation of a Donor Human Milk Program: A Retrospective Cohort Study. J Pediatr. 2019 May 3.
102. Parker LA, Weaver M, Murgas Torrazza RJ, Shuster J, Li N, Krueger C, Neu J. Effect of Aspiration and Evaluation of Gastric Residuals on Intestinal Inflammation, Bleeding, and Gastrointestinal Peptide Level. J Pediatr. 2019 Nov 1
103. Lemas DJ, Mack JA, Schoch JJ, Cacho N, Plasencia E, Rhoton-Vlasak AS, Neu J, Thompson L, Francois M, Patel K, Hogan WR, Lipori GP, Gurka MJ. Postnatal pediatric systemic antibiotic episodes during the first three years of life are not associated with mode of delivery. PLoS One. 2020 Mar 4;15(3): e0229861.
104. Dougherty MW, Kudin O, Mühlbauer M, Neu J, Gharaibeh RZ, Jobin C.  Gut microbiota maturation during early human life induces enterocyte proliferation via microbial metabolites. BMC Microbiol. 2020 Jul 11;20(1):205.
105. Patton L, Li N, Garrett TJ, Ruoss JL, Russell JT, de la Cruz D, Bazacliu C, Polin RA, Triplett EW, Neu, J. Antibiotics Effects on the Fecal Metabolome in Preterm Infants.  Metabolites. 2020 Aug 13;10(8):331.
106. Rozé JC, Ancel PY, Marchand-Martin L, Rousseau C, Montassier E, Monot C, Le Roux K, Butin M, Resche-Rigon M, Aires J, Neu J, Lepage P, Butel MJ; EPIFLORE Study Group. Assessment of Neonatal Intensive Care Unit Practices and Preterm Newborn Gut Microbiota and 2-Year Neurodevelopmental Outcomes.  JAMA Netw Open. 2020 Sep 1;3(9):e2018119.
107. Ruoss JL, Bazacliu C, Russell JT, Cruz D, Li N, Gurka MJ, Filipp SL, Polin RA, Triplett EW, Neu, j. Routine Early Antibiotic Use in SymptOmatic Preterm Neonates: A Pilot Randomized Controlled Trial.  J Pediatr. 2021 Feb;229:294-298.e3
108. Schoch JJ, Miranda N, Garvan CW, Monir RL, Neu J, Lemas DJDuration of neonatal intensive care unit exposure associated with decreased risk of atopic dermatitis.  Pediatr Dermatol. 2020 Oct 16
109. Chen LY, Flood-Grady E, Hentschel A, Wright L, Mkuu R, Young A, Francois M, Neu J, Parker LA, Shenkman E, Krieger JL, Lemas DJ. A Qualitative Study of Pregnant Women's Perspectives on Antibiotic Use for Mom and Child: Implications for Developing Tailored Health Education Interventions.  Antibiotics (Basel). 2020 Oct 15;9(10):704
110. Lure AC, Du X, Black EW, Irons R, Lemas DJ, Taylor JA, Lavilla O, de la Cruz D, Neu J. Using machine learning analysis to assist in differentiating between necrotizing enterocolitis and spontaneous intestinal perforation: A novel predictive analytic tool.   J Pediatr Surg. 2020 Nov 13:S0022-3468(20)30837-X
111. Lemas DJ, Wright L, Flood-Grady E, Francois M, Chen L, Hentschel A, Du X, Hsiao CJ, Chen H, Neu J, Theis RP, Shenkman E, Krieger J. Perspectives of pregnant and breastfeeding women on longitudinal clinical studies that require non-invasive biospecimen collection - a qualitative study.  BMC Pregnancy Childbirth. 2021 Jan 20;21(1):67.
112. Russell JT, Lauren Ruoss J, de la Cruz D, Li N, Bazacliu C, Patton L, McKinley KL, Garrett TJ, Polin RA, Triplett EW, Neu Antibiotics and the developing intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants.  Sci Rep. 2021 Jan 21;11(1):1943.
 
 
 
 
 
 
 
 

HONOURS

HONORS & AWARDS

Midwest and Great Lakes Neonatology Society-Young Investigator of the Year Award, 1981, 1984
 
International Examiner for Medical Students-Chinese U. of Hong Kong (2006).
 
Hong Kong Neonatology Society James Hutchinson Memorial Lecture. Spring, 2006
 
Awarded as organizer of first Society for Pediatric
Research- Research Conference (out of 13 applications) held Oct. 2007 in the Woodlands, Texas.
 
William Silverman Lecture: Columbia University, Oct. 2007, 2009, 2013 and Nov. 2017.
 
L.J. Filer Lecture: University of Iowa, Sept. 2007.
 
Enrique Ostrea Endowed Lecture: Wayne State U., Nov. 2008
Donald Medearis Lectureship, Harvard University, Sept.2010
 
Invited Lecturer for Dr. William Oh‘s 80th birthday celebration and conference. April 26th, 2012. Brown University.
 
Norman Kretchmer Visiting Professorship. Stanford University. Sept. 2012
 
The Branham Nutrition Lecture: Our ―Second Genome: Fetus and Beyond. University of California, San Francisco April 2014
 
The intestinal microbiome, inflammation, and neonatal morbidity. Harrogate, England June 9, 2014.
 
Toronto Sick Children ‘s Hospital and University of Toronto. Development of Our ―Second Genome: Implications for Health and Disease. Keynote Lecture for the Laurence Becker Symposium. June 11, 2014.
 
Hong Kong Neonatology Society James Hutchinson Memorial Lecture. March 24, 2015.
 
International Examiner for Medical Students-Chinese U. of Hong Kong (2015).
 
Visiting Committee to Review Fourth Year Medical School programs at Chinese University of Hong Kong (2015).
 
37th Greater New York Conference on Perinatal Research Nov. 16-18, 2015 Jerry Elliott Memorial Lecture
 
Sharon and Bernard Siegel Endowed Lectureship, UCLA. Feb.19, 2016
 
Paul Swyer visiting Professor—University of Toronto, Toronto Sick Kids Hospital, Oct.
27-28th, 2016
 
2016-Outstanding Educator Award---University of Florida----Selected by Pediatric Residents and Students.
 
Nov. 16, 2018 Braden E. Griffin, MD Memorial Lectureship Award and Lecture, University of Massachusetts.
 
Nov. 28, 2018 Bowman Lecture. Necrotizing Enterocolitis: Why Such an Enigma? University of Manitoba, Winnipeg, Canada.
 
Nov. 2019 University of Florida College of Medicine Term Professorship, which recognizes and rewards significant faculty academic achievements.  
 
2020-University of Florida International Educator of the Year Award.
 
 
 
 

 

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