Prof. Dr. Haresh Kirpalani
University of Pennsylvania, USA and McMaster University, Ontario, Canada
CV
Date: May 2023
Haresh Murli Kirpalani, BM, MSc
Canadian and British Citizen
Email Address: kirpalan@mcmaster.ca
Education:
1971-1976 BM, Southampton University, School of Medicine
1996 MSc in Design, Measurement and Evaluation
McMaster University, Hamilton, Ontario, Canada
Postgraduate Training and Fellowship Appointments:
1976-1977 Internship in General Medicine and Surgery, Portsmouth Hospitals,
UK
1978-1979 Academic Anatomy Demonstrator and Senior House Officer,
Accident & Emergency, Southampton University
1979-1982 Registrar in Pediatrics, University Hospitals of Newcastle-UponTyne, UK
1982-1983 Senior Fellow in Neonatology, Hospital for Sick Children, Toronto,
Canada
Faculty Appointments:
1983-1991 Assistant Professor, Department of Pediatrics, University of Toronto
1991-1997 Associate Professor, Department of Pediatrics, McMaster
University, Faculty of Health Sciences, Hamilton, Canada
1997-2007 Professor, Department of Pediatrics, McMaster University,
Faculty of Health Sciences, Hamilton, Canada
2003-2007 Associate Member, Department of Clinical Epidemiology and
Biostatistics, McMaster University,
Faculty of Health Sciences, Hamilton, Canada
2007-2018 Professor of Pediatrics, Perelman School of Medicine,
University of Pennsylvania, Philadelphia, PA
Since 2011 Professor Emeritus, Department of Pediatrics, McMaster University,
Hamilton, Ontario, Canada
Since 2018 Professor Emeritus, Department of Pediatrics, Perelman School of
Medicine, University of Pennsylvania, Philadelphia, PA
Hospital and Administrative Appointments:
1983-1990 Attending Neonatologist, The Hospital for Sick Children, Toronto
1983-1987 Medical Director, Neonatal Transport Team, The Hospital for Sick
Children, Toronto
1991-2007 Attending Physician in Neonatal and Pediatric Intensive Care,
McMaster Children’s Hospital, Hamilton, Ontario
2007-2018 Attending Neonatologist, The Children’s Hospital of Philadelphia
2007-2018 Director of the Chronic Lung Program, The Children’s Hospital of
Philadelphia, Philadelphia, PA
Specialty Certification:
1982 MRCP, Certification in Pediatrics, Royal College of Physicians, UK
1985 FRCP, Certification in Pediatrics, Royal College of Physicians and
Surgeons of Canada
Licensure: Ontario, Canada, and Pennsylvania, USA until 2018
Awards and Honors:
2005 PAIRO (Professional Association of Interns and Residents of
Ontario) Excellence in Clinical Teaching Award for McMaster
University. Residents of each Ontario Medical School select one
annual awardee for their entire University.
2007 Teaching Excellence Award - Associate-part-time category of the
Department of Clinical Epidemiology & Biostatistics, McMaster
University for teaching in the graduate program
2009 Istvan Seri, MD PhD Neonatal Faculty Teaching Award,
Children’s Hospital of Philadelphia
2013 “When has enough evidence accumulated to make for a standard
of care? Case histories from neonatology”
Reba Michels Hill Lectureship Award, Baylor College of Medicine,
Houston, TX
2015 Mentor of the Year Award, Children's Hospital of Philadelphia
2017 “Can We Prevent Lung Injury in Preterm Infants?”
Reba Michels Hill Lectureship Award, Baylor College of Medicine,
Houston, TX
2020 Honorary Member, SIBEN
(Sociedad Iberoamericana de Neonatologia)
2022 William A Silverman Lectureship Award, Section on Perinatal
Pediatrics, American Academy of Pediatrics
Pediatric Academic Societies Annual Meeting, Denver
This award recognizes an individual whose work has significantly
advanced neonatal ethics or the field of evidence-based medicine.
Memberships in Professional Societies:
1989-2020 Canadian Paediatric Society
1989-2018 American Academy of Pediatrics
1994-2018 Society for Pediatric Research
1994-2018 European Society for Pediatric Research
Since 2009 American Pediatric Society (Elected Member)
Selected other Professional Roles and Activities:
2000 Joint Chair (with Drs. Jacques Lacroix and Jamie Hutchison) of
inaugural meeting that launched the Canadian Critical Care
Pediatric Subgroup of the Canadian Critical Care Trials Group.
https://www.ccctg.ca/our-initiatives/canadian-critical-care-pediatricsubgroup
This effort was supported by a Workshop grant from the Canadian
Institutes of Health Research (CIHR).
2000-2006 Data Safety Monitoring Committee (Member)
Lung Open Ventilation to Decrease Mortality in the Acute
Respiratory Distress Syndrome (LOVS); CIHR
2002-2006 Fetus and Newborn Committee, Canadian Pediatric Society
(Member)
2003-2007 Data Safety Monitoring Committee (Chair)
Vasopressin in Pediatric Vasodilatory Shock
CIHR, Heart and Stroke Foundation, Physicians Services Inc,
Hospital for Sick Children Foundation,
2006-2012 Data Safety Monitoring Committee (Member)
Age of Red Blood Cells in Premature Infants Study (ARIPI), CIHR
2008-2010 Research Ethics Board (Member), Children’s Hospital of
Philadelphia
2009 Co-Chairman, International Symposium of Neonatal -Respiratory
and Intensive Care"; Guangzhou, China; Funded by CIHR and the
National Science Foundation, Beijing, China
2012 Scientific Advisor to Centre for Advanced Research in Newborn
Health (Indian Council of Medical Research). Workshop for
facilitating development of new multi-site studies in newborn health:
Convenor: Dr Vinod Paul, All India Institute of Medical Sciences
2014 Visiting pediatric examiner, Kuwait University
2015 Chair, 3rd international Conference for Evidence-Based
Neonatology, Philadelphia, PA
2015 Co-founded (with Stefan Johansson and Mikael Norman,
Karolinska Institute, Stockholm, Sweden) the International Society
for Evidence-Based Neonatology (EBNEO) with a vision that
neonatal care should be firmly based on the best available
evidence.
Since 2015 Joint Chair of Hot Topics in Neonatology, the largest
international conference of neonatal medicine. This meeting
takes place annually in Washington, DC.
Since 2017 Data Safety Monitoring Committee (Member)
Preventing Lung Disease Using Surfactant + Steroids (PLUSS);
NHMRC Australia
Since 2019 Steering Committee (Member)
Positive end-expiratory pressure levels during resuscitation of
preterm infants at birth (POLAR trial); NHMRC Australia
Since 2019 Steering Committee (Member)
Non-invasive Respiratory Support in Preterm Infants (NOVEL);
Physicians' Services Incorporated Foundation, Hamilton Health
Sciences Foundation
Since 2023 Trial Management Committee (Member) Lungs for Life: Using
wearable oximetry and a virtual ward to improve outcomes of
infants with bronchopulmonary dysplasia (BPD); NHMRC
Australia
Participation in Canadian Grant Review Panels:
2000-2006 CIHR; Randomized Clinical Trials Committee (Member)
Ad hoc Grant Reviewer:
Medical Research Council of Canada, Canadian Institutes of Health Research,
Hospital for Sick Children Foundation, Physicians’ Services Inc. Foundation,
Ontario, National Institutes of Health (NIH).
Editorial Positions:
1985-2007 Residents Handbook of Neonatology; Co-Editor through 3 editions
2009 Manual of Pediatric Intensive Care; Co-Editor
Since 2000 Imaging of the Newborn, now published by Cambridge University
Press; Co-Editor through 2 editions to date; 3rd edition in progress.
2016 Non-Invasive Ventilation; Clinics in Perinatology; Co-Editor
2018 Rudolphs’ Pediatrics, 23rd Ed. Section 4: Newborn; Co-Editor
Since 2018 Cochrane Neonatal, Associate Editor
Since 2019 The Journal of Maternal-Fetal & Neonatal Medicine; Editorial Board
Since 2020 Pediatric Medicine; Editorial Board
Ad hoc Journal Reviewer:
N Engl J Med, American Journal of Respiratory and Critical Care Medicine,
Pediatrics, Journal of Pediatrics, JAMA Pediatrics, Archives of Diseases in
Childhood, Archives of Diseaases in Childhood, Fetal and Neonatal Edition,
Cochrane Neonatal, Pediatric Research, Journal of Perinatology, Acta
Paediatrica, Neonatology, Jornal de Pediatria.
PUBLICATIONS
Peer-Reviewed Publications: N = 165
1. Mukerji A, Rempel E, Thabane L, Johnson H, Schmolzer G, Law BHY, Jani P, Tracy M,
Rottkamp C, Keszler M, Kirpalani H, Shah PS; NOVEL Trial Group. High
continuous positive airway pressures versus non-invasive positive pressure ventilation
in preterm neonates: protocol for a multicentre pilot randomised controlled trial. BMJ
Open. 2023 Feb 14;13(2):e069024.
2. Kaempf JW, Guillen U, Litt JS, Zupancic JAF, Kirpalani H. Change in
neurodevelopmental outcomes for extremely premature infants over time: a
systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2022 Oct
21:fetalneonatal-2022-324457.
3. Bamat NA, Orians CM, Abbasi S, Morley CJ, Ross Russell R, Panitch HB, Handley
SC, Foglia EE, Posencheg MA, Kirpalani H. Use of ventilation/perfusion mismatch
to guide individualised CPAP level selection in preterm infants: a feasibility trial. Arch
Dis Child Fetal Neonatal Ed. 2023 Mar;108(2):188-193.
4. Schouten E, Haupt J, Ramirez J, Sillett N, Nielsen C, Clarke A, Matkin L, Joseph A,
Been J, Bolaños González I, Cheong J, Daly M, Kirpalani H, Mader S, Maria A,
Matijasevich A, Mittal R, Mutesu-Kapembwa K, Vavouraki E, Webbe J, Wolke D, Zeitlin
J, Flemmer A. Standardized Outcome Measures for Preterm and Hospitalized
Neonates: An ICHOM Standard Set. Neonatology. 2022;119(4):443-454.
5. Chock VY, Smith E, Tan S, Ball MB, Das A, Hintz SR, Kirpalani H, Bell EF,Chalak LF,
Carlo WA, Cotten CM, Widness JA, Kennedy KA, Ohls RK, Seabrook RB, Patel RM,
Laptook AR, Mancini T, Sokol GM, Walsh MC, Yoder BA, Poindexter BB, Chawla S,
D'Angio CT, Higgins RD, Van Meurs KP; Eunice Kennedy Shriver National Institute of
Child Health and Human Development Neonatal Research Network. Early brain and
abdominal oxygenation in extremely low birth weight infants. Pediatr Res. 2022
Oct;92(4):1034-1041.
6. Nabwera HM, Ekhaguere OA, Kirpalani H, Burgoine K, Ezeaka CV, Otieno W, Allen SJ,
Embleton ND; Neonatal Nutrition Network (NeoNuNet). Caffeine for the care of preterm
infants in sub-Saharan Africa: a missed opportunity? BMJ Glob Health. 2021
Dec;6(12):e007682.
7. Bamat N, Fierro J, Mukerji A, Wright CJ, Millar D, Kirpalani H. Nasal continuous positive
airway pressure levels for the prevention of morbidity and mortality in preterm infants.
Cochrane Database Syst Rev. 2021 Nov 30;11(11):CD012778.
8. Foglia EE, Kirpalani H, Ratcliffe SJ, Davis PG, Thio M, Hummler H, Lista G, Cavigioli F,
Schmölzer GM, Keszler M, Te Pas AB. Sustained Inflation Versus Intermittent Positive
Pressure Ventilation for Preterm Infants at Birth: Respiratory Function and Vital Sign
Measurements. J Pediatr. 2021 Dec;239:150-154.e1.
9. Kirpalani H, Bell EF, Hintz SR, Tan S, Schmidt B, Chaudhary AS, Johnson KJ,
Crawford MM, Newman JE, Vohr BR, Carlo WA, D'Angio CT, Kennedy KA, Ohls RK,
Poindexter BB, Schibler K, Whyte RK, Widness JA, Zupancic JAF, Wyckoff MH, Truog
WE, Walsh MC, Chock VY, Laptook AR, Sokol GM, Yoder BA, Patel RM, Cotten CM,
Carmen MF, Devaskar U, Chawla S, Seabrook R, Higgins RD, Das A; Eunice Kennedy
Shriver NICHD Neonatal Research Network. Higher or Lower Hemoglobin Transfusion
Thresholds for Preterm Infants. N Engl J Med. 2020 Dec 31;383(27):2639-2651.
10.Bamat NA, Nelin TD, Eichenwald EC, Kirpalani H, Laughon MM, Jackson WM,
Jensen EA, Gibbs KA, Lorch SA. Loop Diuretics in Severe Bronchopulmonary
Dysplasia: Cumulative Use and Associations with Mortality and Age at Discharge.
J Pediatr. 2021 Apr;231:43-49.e3.
11.Dworetz AR, Natarajan G, Langer J, Kinlaw K, James JR, Bidegain M, Das A,
Poindexter B, Bell EF, Cotten CM, Kirpalani H, Shankaran S, Stoll BJ; Eunice
Kennedy Shriver National Institute of Child Health; Human Development Neonatal
Research Network. Withholding or withdrawing life-sustaining treatment in
extremely low gestational age neonates. Arch Dis Child Fetal Neonatal Ed. 2021
May;106(3):238-243.
12.Maratta C, Hutchison K, Moore GP, Bagshaw SM, Granton J, Kirpalani H,
Stelfox HT, Ferguson N, Cook D, Parshuram CS. In-House, Overnight Physician
Staffing: A Cross-Sectional Survey of Canadian Adult ICUs. Crit Care Med. 2020
Dec;48(12):e1203-e1210.
13.Chandrasekharan P, Lakshminrusimha S, Chowdhury D, Van Meurs K, Keszler M,
Kirpalani H, Das A, Walsh MC, McGowan EC, Higgins RD; NRN STEERING
COMMITTEE. Early Hypoxic Respiratory Failure in Extreme Prematurity: Mortality and
Neurodevelopmental Outcomes. Pediatrics. 2020 Oct;146(4):e20193318.
14.Kovatis KZ, Di Fiore JM, Martin RJ, Abbasi S, Chaundhary AS, Hoover S, Zhang
Z, Kirpalani H. Effect of Blood Transfusions on Intermittent Hypoxic Episodes in
a Prospective Study of Very Low Birth Weight Infants. J Pediatr. 2020 Jul;222:65-70.
15.Foglia EE, Te Pas AB, Kirpalani H, Davis PG, Owen LS, van Kaam AH, Onland W,
Keszler M, Schmölzer GM, Hummler H, Lista G, Dani C, Bastrenta P, Localio R,
Ratcliffe SJ. Sustained Inflation vs Standard Resuscitation for Preterm Infants:
A Systematic Review and Meta-analysis. JAMA Pediatr. 2020 Apr 1;174(4):e195897.
16.Wu KY, Jensen EA, White AM, Wang Y, Biko DM, Nilan K, Fraga MV, Mercer-Rosa
L, Zhang H, Kirpalani H. Characterization of Disease Phenotype in Very Preterm
Infants with Severe Bronchopulmonary Dysplasia. Am J Respir Crit Care Med. 2020
Jun1;201(11):1398-1406.
17.Rüdiger M, Kirpalani H, Steinhorn R, Davis JM, Thebaud B. How to introduce MSCbased therapy for the developing lung safely into clinical care? Pediatr Res. 2020
Sep;88(3):365-368.
18.Kirpalani H, Keszler M, Foglia EE, Davis P, Ratcliffe S. Considering the Validity of the
SAIL Trial-A Navel Gazers Guide to the SAIL Trial. Front Pediatr. 2019 Nov 27;7:495.
19.Jensen EA, Zhang H, Feng R, Dysart K, Nilan K, Munson DA, Kirpalani H.
Individualising care in severe bronchopulmonary dysplasia: a series of N-of-1 trials
comparing transpyloric and gastric feeding. Arch Dis Child Fetal Neonatal Ed. 2020
Jul;105(4):399-404
20.Bourque SL, Roberts RS, Wright CJ, Kirpalani H, Lemyre B, Millar D, Bamat NA. Nasal
Intermittent Positive Pressure Ventilation Versus Nasal Continuous Positive Airway
Pressure to Prevent Primary Noninvasive Ventilation Failure in Extremely Low
Birthweight Infants. J Pediatr. 2020 Jan;216:218-221.e1
21.Ekhaguere O, Patel S, Kirpalani H. Nasal Intermittent Mandatory Ventilation Versus
Nasal Continuous Positive Airway Pressure Before and After Invasive Ventilatory
Support. Clin Perinatol. 2019 Sep;46(3):517-536.
22.Fraga MV, Dysart KC, Rintoul N, Chaudhary AS, Ratcliffe SJ, Fedec A, Kren S, Cohen
MS, Kirpalani H. Cardiac Output Measurement Using the Ultrasonic Cardiac Output
Monitor: A Validation Study in Newborn Infants. Neonatology. 2019;116(3):260-268.
23.Kirpalani H. Control of Bias Has Been Recognized as Important for a Long
Time - but Are We Finally in Control? Neonatology. 2019;116(2):185-187.
24.Ansems SM, Kirpalani H, Mercer-Rosa L, Wang Y, Hopper RK, Fraga MV, Jensen
EA. Patent Ductus Arteriosus and the Effects of Its Late Closure in Preterm Infants with
Severe Bronchopulmonary Dysplasia. Neonatology. 2019;116(3):236-243.
25.Bamat NA, Kirpalani H, Feudtner C, Jensen EA, Laughon MM, Zhang H, Monk HM,
Passarella M, Lorch SA. Medication use in infants with severe bronchopulmonary
dysplasia admitted to United States children's hospitals. J Perinatol. 2019
Sep;39(9):1291-1299.
26.Avitabile CM, Ansems S, Wang Y, Fraga MV, Kirpalani HM, Zhang H, Mercer-Rosa
L, Jensen EA. Accuracy of Brain Natriuretic Peptide for Diagnosing Pulmonary
Hypertension in Severe Bronchopulmonary Dysplasia. Neonatology. 2019;116(2):147-
153.
27.Jensen EA, Dysart K, Gantz MG, McDonald S, Bamat NA, Keszler M, Kirpalani H,
Laughon MM, Poindexter BB, Duncan AF, Yoder BA, Eichenwald EC, DeMauro SB.
The Diagnosis of Bronchopulmonary Dysplasia in Very Preterm Infants. An Evidencebased Approach. Am J Respir Crit Care Med. 2019 Sep 15;200(6):751-759.
28.Guillén Ú, Mackley A, Laventhal N, Kukora S, Christ L, Derrick M, Batza J, Ghavam S,
Kirpalani H. Evaluating the Use of a Decision Aid for Parents Facing Extremely
Premature Delivery: A Randomized Trial. J Pediatr. 2019 Jun;209:52-60.e1.
29.Napolitano N, Jalal K, McDonough JM, Monk HM, Zhang H, Jensen E, Dysart KC,
Kirpalani HM, Panitch HB. Identifying and treating intrinsic PEEP in infants with severe
bronchopulmonary dysplasia. Pediatr Pulmonol. 2019 Jul;54(7):1045-1051.
30.Kirpalani H, Ratcliffe SJ, Keszler M, Davis PG, Foglia EE, Te Pas A, Fernando M,
Chaudhary A, Localio R, van Kaam AH, Onland W, Owen LS, Schmölzer GM, Katheria
A, Hummler H, Lista G, Abbasi S, Klotz D, Simma B, Nadkarni V, Poulain FR, Donn SM,
Kim HS, Park WS, Cadet C, Kong JY, Smith A, Guillen U, Liley HG, Hopper AO,
Tamura M; SAIL Site Investigators. Effect of Sustained Inflations vs Intermittent Positive
Pressure Ventilation on Bronchopulmonary Dysplasia or Death Among Extremely
Preterm Infants: The SAIL Randomized Clinical Trial.
JAMA. 2019 Mar 26;321(12):1165-1175.
31.Burris HH, Lorch SA, Kirpalani H, Pursley DM, Elovitz MA, Clougherty JE. Racial
disparities in preterm birth in USA: a biosensor of physical and social environmental
exposures. Arch Dis Child. 2019 Oct;104(10):931-935.
32.Bamat N, Fierro J, Wang Y, Millar D, Kirpalani H. Positive end-expiratory pressure for
preterm infants requiring conventional mechanical ventilation for respiratory distress
syndrome or bronchopulmonary dysplasia. Cochrane Database Syst Rev. 2019 Feb
26;2(2):CD004500.
33.Burris HH, Hwang SS, Collins JW Jr, Kirpalani H, Wright CJ. Re-conceptualizing
Associations between Race and Morbidities of Extreme Prematurity. J Pediatr. 2019
Apr;207:10-14.e1.
34.van Heesewijk AE, Rush ML, Schmidt B, Kirpalani H, DeMauro SB. Agreement between
study designs: a systematic review comparing observational studies and randomized
trials of surgical treatments for necrotizing enterocolitis. J Matern Fetal Neonatal Med.
2020 Jun;33(12):1965-1973.
35.Brady JM, Zhang H, Kirpalani H, DeMauro SB. Living with Severe Bronchopulmonary
Dysplasia-Parental Views of Their Child's Quality of Life. J Pediatr. 2019 Apr;207:117-
122.
36.Manja V, Guyatt G, Lakshminrusimha S, Jack S, Kirpalani H, Zupancic JAF, Dukhovny
D, You JJ, Monteiro S. Factors influencing decision making in neonatology: inhaled
nitric oxide in preterm infants. J Perinatol. 2019 Jan;39(1):86-94.
37.Manja V, Kirpalani H, Lakshminrusimha S. Factors influencing decision-making:
Delayed hypothermia in a late preterm infants with hypoxic-ischemic encephalopathy.
Early Hum Dev. 2019 Jan;128:102-103.
38.Zhang H, Dysart K, Kendrick DE, Li L, Das A, Hintz SR, Vohr BR, Stoll BJ, Higgins RD,
Nelin L, Carlton DP, Walsh MC, Kirpalani H; Eunice Kennedy Shriver National Institute
of Child Health and Human Development Neonatal Research Network. Prolonged
respiratory support of any type impacts outcomes of extremely low birth weight infants.
Pediatr Pulmonol. 2018 Oct;53(10):1447-1455.
39.Luo J, Shepard S, Nilan K, Wood A, Monk HM, Jensen EA, Harrington AT, Maschhoff
K, Kirpalani H, Feng Z, Zhang H. Improved growth and developmental activity post
tracheostomy in preterm infants with severe BPD. Pediatr Pulmonol. 2018
Sep;53(9):1237-1244.
40.Ekhaguere OA, Mairami AB, Kirpalani H. Risk and benefits of Bubble Continuous
Positive Airway Pressure for neonatal and childhood respiratory diseases in Low- and
Middle-Income countries. Paediatr Respir Rev. 2019 Feb;29:31-36.
41.Drago MJ, Guillén U, Schiaratura M, Batza J, Zygmunt A, Mowes A, Munson D,
Lorenz JM, Farkouh-Karoleski C, Kirpalani H. Constructing a Culturally Informed
Spanish Decision-Aid to Counsel Latino Parents Facing Imminent Extreme Premature
Delivery. Matern Child Health J. 2018 Jul;22(7):950-957.
42.Brady JM, Pouppirt N, Bernbaum J, D'Agostino JA, Gerdes M, Hoffman C, Cook
N, Hurt H, Kirpalani H, DeMauro SB. Why do children with severe bronchopulmonary
dysplasia not attend neonatal follow-up care? Parental views of barriers. Acta
Paediatr. 2018 Jun;107(6):996-1002.
43.Bamat NA, Guevara JP, Bryan M, Roberts RS, Yoder BA, Lemyre B, Chiu A, Millar D,
Kirpalani H. Variation in Positive End-Expiratory Pressure Levels for Mechanically
Ventilated Extremely Low Birth Weight Infants. J Pediatr. 2018 Mar;194:28-33.e5.
44.Lakshminrusimha S, Keszler M, Kirpalani H, Van Meurs K, Chess P, Ambalavanan
N, Yoder B, Fraga MV, Hedrick H, Lally KP, Nelin L, Cotten M, Klein J, Guilford S,
Williams A, Chaudhary A, Gantz M, Gabrio J, Chowdhury D, Zaterka-Baxter K, Das A,
Higgins RD. Milrinone in congenital diaphragmatic hernia - a randomized pilot trial:
study protocol, review of literature and survey of current practices. Matern Health
Neonatol Perinatol. 2017 Nov 27;3:27.
45.Guillen U, Kirpalani H. Ethical implications of the use of decision aids for antenatal
counseling at the limits of gestational viability. Semin Fetal Neonatal Med. 2018
Feb;23(1):25-29.
46.Skibo M, Guillen U, Zhang H, Munson D, Mackley A, Nilan K, Kirpalani H. Constructing
a relevant decision aid for parents of children with bronchopulmonary dysplasia. J
Perinatol. 2017 Dec;37(12):1341-1345.
47.Hay SC, Kirpalani H, Viner C, Soll R, Dukhovny D, Mao WY, Profit J, DeMauro SB,
Zupancic JAF. Do trials reduce uncertainty? Assessing impact through cumulative
meta-analysis of neonatal RCTs. J Perinatol. 2017 Nov;37(11):1215-1219.
48.James J, Munson D, DeMauro SB, Langer JC, Dworetz AR, Natarajan G, Bidegain
M, Fortney CA, Seabrook R, Vohr BR, Tyson JE, Bell EF, Poindexter BB, Shankaran
S, Higgins RD, Das A, Stoll BJ, Kirpalani H; Eunice Kennedy Shriver National
Institute of Child Health and Human Development Neonatal Research Network.
Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of
Life Support. J Pediatr. 2017 Nov;190:118-123.e4. Erratum in: J Pediatr. 2019
Apr;207:270.
49.Foglia EE, Jensen EA, Kirpalani H. Delivery room interventions to prevent
bronchopulmonary dysplasia in extremely preterm infants. J Perinatol. 2017
Nov;37(11):1171-1179.
50.Andersen CC, Hodyl NA, Kirpalani HM, Stark MJ. A Theoretical and Practical Approach
to Defining "Adequate Oxygenation" in the Preterm Newborn. Pediatrics. 2017
Apr;139(4):e20161117.
51.Srinivasan L, Page G, Kirpalani H, Murray JC, Das A, Higgins RD, Carlo WA, Bell EF,
Goldberg RN, Schibler K, Sood BG, Stevenson DK, Stoll BJ, Van Meurs KP, Johnson
KJ, Levy J, McDonald SA, Zaterka-Baxter KM, Kennedy KA, Sánchez PJ, Duara S,
Walsh MC, Shankaran S, Wynn JL, Cotten CM; Eunice Kennedy Shriver National
Institute of Child Health and Human Development Neonatal Research Network.
Genome-wide association study of sepsis in extremely premature infants.
Arch Dis Child Fetal Neonatal Ed. 2017 Sep;102(5):F439-F445.
52.Lemyre B, Davis PG, De Paoli AG, Kirpalani H. Nasal intermittent positive pressure
ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for
preterm neonates after extubation. Cochrane Database Syst Rev. 2017 Feb
1;2(2):CD003212.
53.Giaccone A, Zuppa AF, Sood B, Cohen MS, O'Byrne ML, Moorthy G, Mathur A,
Kirpalani H. Milrinone Pharmacokinetics and Pharmacodynamics in Neonates with
Persistent Pulmonary Hypertension of the Newborn. Am J Perinatol. 2017
Jul;34(8):749-758.
54.Backes CH, Rivera BK, Bridge JA, Armstrong AK, Boe BA, Berman DP, Fick T, Holzer
RJ, Hijazi ZM, Abadir S, Justino H, Bergersen L, Smith CV, Kirpalani H. Percutaneous
Patent Ductus Arteriosus (PDA) Closure During Infancy: A Meta-analysis. Pediatrics.
2017 Feb;139(2):e20162927.
55.Srinivasan L, Swarr DT, Sharma M, Cotten CM, Kirpalani H. Systematic Review and
Meta-analysis: Gene Association Studies in Neonatal Sepsis. Am J Perinatol. 2017
Jun;34(7):684-692.
56.Abman SH, Collaco JM, Shepherd EG, Keszler M, Cuevas-Guaman M, Welty SE,
Truog WE, McGrath-Morrow SA, Moore PE, Rhein LM, Kirpalani H, Zhang H, Gratny
LL, Lynch SK, Curtiss J, Stonestreet BS, McKinney RL, Dysart KC, Gien J, Baker
CD, Donohue PK, Austin E, Fike C, Nelin LD; Bronchopulmonary Dysplasia
Collaborative. Interdisciplinary Care of Children with Severe Bronchopulmonary
Dysplasia. J Pediatr. 2017 Feb;181:12-28.e1.
57.Hay S, Zupancic JA, Flannery DD, Kirpalani H, Dukhovny D. Should we believe in
transfusion-associated enterocolitis? Applying a GRADE to the literature.
Semin Perinatol. 2017 Feb;41(1):80-91.
58.Waitz M, Mense L, Kirpalani H, Lemyre B. Nasal Intermittent Positive Pressure
Ventilation for Preterm Neonates: Synchronized or Not? Clin Perinatol. 2016
Dec;43(4):799-816.
59.Guillén Ú, Suh S, Wang E, Stickelman V, Kirpalani H. Development of a video decision
aid to inform parents on potential outcomes of extreme prematurity. J Perinatol. 2016
Nov;36(11):939-943.
60.Mowitz ME, Zupancic JA, Millar D, Kirpalani H, Gaulton JS, Roberts RS, Mao W,
Dukhovny D. Prospective economic evaluation alongside the non-invasive ventilation
trial. J Perinatol. 2017 Jan;37(1):61-66.
61.Kirpalani H, Truog WE, D'Angio CT, Cotten M. Recent controversies on comparative
effectiveness research investigations: Challenges, opportunities, and pitfalls.
Semin Perinatol. 2016 Oct;40(6):341-347.
62.Wright CJ, Polin RA, Kirpalani H. Continuous Positive Airway Pressure to Prevent
Neonatal Lung Injury: How Did We Get Here, and How Do We Improve? J Pediatr. 2016
Jun;173:17-24.e2.
63.Bamat N, Jensen EA, Kirpalani H. Duration of continuous positive airway pressure in
premature infants. Semin Fetal Neonatal Med. 2016 Jun;21(3):189-95.
64.Jensen EA, Chaudhary A, Bhutta ZA, Kirpalani H. Non-invasive respiratory support for
infants in low- and middle-income countries. Semin Fetal Neonatal Med. 2016
Jun;21(3):181-8.
65.Dukhovny D, Pursley DM, Kirpalani HM, Horbar JH, Zupancic JA. Evidence, Quality,
and Waste: Solving the Value Equation in Neonatology. Pediatrics. 2016
Mar;137(3):e20150312.
66.Srinivasan L, Kirpalani H, Cotten CM. Elucidating the role of genomics in neonatal
sepsis. Semin Perinatol. 2015 Dec;39(8):611-6.
67.Foglia EE, DeMauro SB, Dysart K, Kirpalani H. When has enough evidence
accumulated to change neonatal practice? Semin Fetal Neonatal Med. 2015
Dec;20(6):424-30.
68.Guillén Ú, Weiss EM, Munson D, Maton P, Jefferies A, Norman M, Naulaers G, Mendes
J, Justo da Silva L, Zoban P, Hansen TW, Hallman M, Delivoria-Papadopoulos M,
Hosono S, Albersheim SG, Williams C, Boyle E, Lui K, Darlow B, Kirpalani H.
Guidelines for the Management of Extremely Premature Deliveries: A Systematic
Review. Pediatrics. 2015 Aug;136(2):343-50.
69.Millar D, Lemyre B, Kirpalani H, Chiu A, Yoder BA, Roberts RS. A comparison of bilevel
and ventilator-delivered non-invasive respiratory support. Arch Dis Child Fetal Neonatal
Ed. 2016 Jan;101(1):F21-5.
70.Foglia EE, Owen LS, Thio M, Ratcliffe SJ, Lista G, Te Pas A, Hummler H, Nadkarni V,
Ades A, Posencheg M, Keszler M, Davis P, Kirpalani H. Sustained Aeration of Infant
Lungs (SAIL) trial: study protocol for a randomized controlled trial. Trials. 2015 Mar
15;16:95.
71.Bamat N, Ghavam S, Liu Y, DeMauro SB, Jensen EA, Roberts R, Yoder BA, Kirpalani
H. Reliability of a Noninvasive Measure of V./Q. Mismatch for Bronchopulmonary
Dysplasia. Ann Am Thorac Soc. 2015 May;12(5):727-33.
72.Parshuram CS, Amaral AC, Ferguson ND, Baker GR, Etchells EE, Flintoft V, Granton J,
Lingard L, Kirpalani H, Mehta S, Moldofsky H, Scales DC, Stewart TE, Willan AR,
Friedrich JO; Canadian Critical Care Trials Group. Patient safety, resident well-being
and continuity of care with different resident duty schedules in the intensive care unit: a
randomized trial. CMAJ. 2015 Mar17;187(5):321-9.
73.Lemyre B, Davis PG, De Paoli AG, Kirpalani H. Nasal intermittent positive pressure
ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for
preterm neonates after extubation. Cochrane Database Syst Rev. 2014 Sep
4;(9):CD003212. Update in: CochraneDatabase Syst Rev. 2017 Feb 01;2:CD003212.
74.DeMauro SB, Cairnie J, D'Ilario J, Kirpalani H, Schmidt B. Honesty, trust, and respect
during consent discussions in neonatal clinical trials. Pediatrics. 2014 Jul;134(1):e1-3.
75.Ghavam S, Batra D, Mercer J, Kugelman A, Hosono S, Oh W, Rabe H, Kirpalani H.
Effects of placental transfusion in extremely low birthweight infants: meta-analysis of
long- and short-term outcomes. Transfusion. 2014 Apr;54(4):1192-8.
76.Jensen EA, Munson DA, Zhang H, Blinman TA, Kirpalani H. Anti-gastroesophageal
reflux surgery in infants with severe bronchopulmonary dysplasia. Pediatr Pulmonol.
2015 Jun;50(6):584-7.
77.DeMauro SB, Millar D, Kirpalani H. Noninvasive respiratory support for neonates. Curr
Opin Pediatr. 2014 Apr;26(2):157-62.
78.Jefferies AL, Kirpalani H, Albersheim SG, Lynk A. Counselling and management for
anticipated extremely preterm birth. Paediatr Child Health. 2014 Jan;19(1):25-6.
79.DeMauro SB, D'Agostino JA, Bann C, Bernbaum J, Gerdes M, Bell EF, Carlo WA,
D'Angio CT, Das A, Higgins R, Hintz SR, Laptook AR, Natarajan G, Nelin L, Poindexter
BB, Sanchez PJ, Shankaran S, Stoll BJ, Truog W, Van Meurs KP, Vohr B, Walsh MC,
Kirpalani H; Eunice Kennedy Shriver National Institute of Child Health
and Human Development Neonatal Research Network. Developmental outcomes of
very preterm infants with tracheostomies. J Pediatr. 2014 Jun;164(6):1303-10.e2.
80.Jefferies AL, Kirpalani HM; Canadian Paediatric Society Fetus and Newborn
Committee. Counselling and management for anticipated extremely preterm birth.
Paediatr Child Health. 2012 Oct;17(8):443-6.
81.Kirpalani H, Millar D, Lemyre B, Yoder BA, Chiu A, Roberts RS; NIPPV Study Group.
A trial comparing noninvasive ventilation strategies in preterm infants.
N Engl J Med. 2013 Aug 15;369(7):611-20.
82.Muchantef K, Epelman M, Darge K, Kirpalani H, Laje P, Anupindi SA.
Sonographic and radiographic imaging features of the neonate with necrotizing
enterocolitis: correlating findings with outcomes. Pediatr Radiol. 2013
Nov;43(11):1444-52.
83.Kirpalani H, Zupancic JA. Do transfusions cause necrotizing enterocolitis?
The complementary role of randomized trials and observational studies. Semin
Perinatol. 2012 Aug;36(4):269-76.
84.Guillén U, Cummings JJ, Bell EF, Hosono S, Frantz AR, Maier RF, Whyte RK, Boyle E,
Vento M, Widness JA, Kirpalani H. International survey of transfusion practices for
extremely premature infants. Semin Perinatol. 2012 Aug;36(4):244-7.
85.Abbasi S, Sivieri E, Roberts R, Kirpalani H. Accuracy of tidal volume, compliance, and
resistance measurements on neonatal ventilator displays: an in vitro assessment.
Pediatr Crit Care Med. 2012 Jul;13(4):e262-8.
86.Guillén U, DeMauro S, Ma L, Zupancic J, Roberts R, Schmidt B, Kirpalani H.
Relationship between attrition and neurodevelopmental impairment rates in extremely
preterm infants at 18 to 24 months: a systematic review. Arch Pediatr Adolesc Med.
2012 Feb;166(2):178-84.
87.Bamat N, Millar D, Suh S, Kirpalani H. Positive end expiratory pressure for preterm
infants requiring conventional mechanical ventilation for respiratory distress syndrome
or bronchopulmonary dysplasia. Cochrane Database Syst Rev.
2012 Jan 18;1:CD004500.CD004500.pub2. Update in: Cochrane Database Syst Rev.
2019 Feb 26;2:CD004500.
88.Whyte R, Kirpalani H. Low versus high haemoglobin concentration threshold for blood
transfusion for preventing morbidity and mortality in very low birth weight infants.
Cochrane Database Syst Rev. 2011 Nov 9;(11):CD000512.
89.Guillén Ú, Suh S, Munson D, Posencheg M, Truitt E, Zupancic JA, Gafni A,
Kirpalani H. Development and pretesting of a decision-aid to use when counseling
parents facing imminent extreme premature delivery. J Pediatr. 2012 Mar;160(3):382-7.
90.DeMauro SB, Giaccone A, Kirpalani H, Schmidt B. Quality of reporting of neonatal and
infant trials in high-impact journals. Pediatrics. 2011 Sep;128(3):e639-44
91.Guillen U, DeMauro S, Ma L, Zupancic J, Wang E, Gafni A, Kirpalani H.
Survival rates in extremely low birthweight infants depend on the denominator: avoiding
potential for bias by specifying denominators. Am J Obstet Gynecol. 2011
Oct;205(4):329.e1-7.
92.Kamholz KL, Dukhovny D, Kirpalani H, Whyte RK, Roberts RS, Wang N, Mao W,
Zupancic JA; Premature Infants in Need of Transfusion Study Group. Economic
evaluation alongside the Premature Infants in Need of Transfusion randomised
controlled trial. Arch Dis Child Fetal Neonatal Ed. 2012 Mar;97(2):F93-8.
93.Wright CJ, Kirpalani H. Targeting inflammation to prevent bronchopulmonary dysplasia:
can new insights be translated into therapies? Pediatrics. 2011 Jul;128(1):111-26.
94.Jacobs SE, Morley CJ, Inder TE, Stewart MJ, Smith KR, McNamara PJ, Wright
IM, Kirpalani HM, Darlow BA, Doyle LW; Infant Cooling Evaluation Collaboration.
Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic
encephalopathy: a randomized controlled trial. Arch Pediatr Adolesc Med. 2011
Aug;165(8):692-700.
95.Binenbaum G, Ying GS, Quinn GE, Dreiseitl S, Karp K, Roberts RS, Kirpalani H;
Premature Infants in Need of Transfusion Study Group. A clinical prediction model to
stratify retinopathy of prematurity risk using postnatal weight gain.
Pediatrics. 2011 Mar;127(3):e607-14.
96.Ma L, Liu C, Wang Y, Li S, Zhai S, Gu X, Liu F, Yan A, Guo W, Li Y, Xiao M, Yin J, Li Y,
Liu X, Wang R, Kirpalani H, Sun B; Hebei Neonatal Network Study Group. Mortality of
neonatal respiratory failure related to socioeconomic factors in Hebei province of China.
Neonatology. 2011;100(1):14-22.
97.Bassler D, Kreutzer K, McNamara P, Kirpalani H. Milrinone for persistent
pulmonary hypertension of the newborn. Cochrane Database Syst Rev. 2010 Nov
10;2010(11):CD007802.
98.Bassler D, Briel M, Montori VM, Lane M, Glasziou P, Zhou Q, Heels-Ansdell D, Walter
SD, Guyatt GH; STOPIT-2 Study Group; Flynn DN, Elamin MB, Murad MH, Abu Elnour
NO, Lampropulos JF, Sood A, Mullan RJ, Erwin PJ, Bankhead CR, Perera R, Ruiz
Culebro C, You JJ, Mulla SM, Kaur J, Nerenberg KA, Schünemann H, Cook DJ, Lutz K,
Ribic CM, Vale N, Malaga G, Akl EA, Ferreira-Gonzalez I, Alonso-Coello P, Urrutia G,
Kunz R, Bucher HC, Nordmann AJ, Raatz H, da Silva SA, Tuche F, Strahm B,
Djulbegovic B, Adhikari NK, Mills EJ, Gwadry-Sridhar F, Kirpalani H, Soares HP,
Karanicolas PJ, Burns KE, Vandvik PO, Coto-Yglesias F, Chrispim PP, Ramsay T.
Stopping randomized trials early for benefit and estimation of treatment effects:
systematic review and meta-regression analysis. JAMA. 2010 Mar 24;303(12):1180-7.
99.Crowley M, Kirpalani H. A rational approach to red blood cell transfusion
in the neonatal ICU. Curr Opin Pediatr. 2010 Apr;22(2):151-7.
100.Briel M, Lane M, Montori VM, Bassler D, Glasziou P, Malaga G, Akl EA,
Ferreira-Gonzalez I, Alonso-Coello P, Urrutia G, Kunz R, Culebro CR, da Silva
SA, Flynn DN, Elamin MB, Strahm B, Murad MH, Djulbegovic B, Adhikari NK, Mills
EJ, Gwadry-Sridhar F, Kirpalani H, Soares HP, Abu Elnour NO, You JJ, Karanicolas
PJ, Bucher HC, Lampropulos JF, Nordmann AJ, Burns KE, Mulla SM, Raatz H, Sood A,
Kaur J, Bankhead CR, Mullan RJ, Nerenberg KA, Vandvik PO, Coto-Yglesias F,
Schünemann H, Tuche F, Chrispim PP, Cook DJ, Lutz K, Ribic CM, Vale N, Erwin PJ,
Perera R, Zhou Q, Heels-Ansdell D, Ramsay T, Walter SD, Guyatt GH. Stopping
randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim
Truncation-2 (STOPIT-2). Trials. 2009 Jul 6;10:49.
101.Vanderveen JA, Bassler D, Robertson CM, Kirpalani H. Early interventions
involving parents to improve neurodevelopmental outcomes of premature infants: a
meta-analysis. J Perinatol. 2009 May;29(5):343-51.
102.Whyte RK, Kirpalani H, Asztalos EV, Andersen C, Blajchman M, Heddle N,
LaCorte M, Robertson CM, Clarke MC, Vincer MJ, Doyle LW, Roberts RS; PINTOS
Study Group. Neurodevelopmental outcome of extremely low birth weight infants
randomly assigned to restrictive or liberal hemoglobin thresholds for blood
transfusion. Pediatrics. 2009 Jan;123(1):207-13.
103.Williams C, Cairnie J, Fines V, Patey C, Schwarzer K, Aylward J, Lohfeld L,
Kirpalani H; With Care team. Construction of a parent-derived questionnaire to
measure end-of-life care after withdrawal of life-sustaining treatment in the neonatal
intensive care unit. Pediatrics. 2009 Jan;123(1):e87-95.
104.Kirpalani H. Child well being in rich countries - Canada's ranking.
Paediatr Child Health. 2007 May;12(5):380.
105.Hutzal CE, Boyle EM, Kenyon SL, Nash JV, Winsor S, Taylor DJ, Kirpalani H.
Use of antibiotics for the treatment of preterm parturition and prevention of
neonatal morbidity: a metaanalysis. Am J Obstet Gynecol. 2008 Dec;199(6):620.e1-8
106.Reise K, Monkman S, Kirpalani H. The use of the Laerdal infant resuscitator
results in the delivery of high oxygen fractions in the absence of a blender.
Resuscitation. 2009 Jan;80(1):120-5.
107.Schmidt B, Roberts R, Millar D, Kirpalani H. Evidence-based neonatal drug therapy for
prevention of bronchopulmonary dysplasia in very-low-birth-weight infants.
Neonatology. 2008;93(4):284-7.
108.Williams C, Munson D, Zupancic J, Kirpalani H. Supporting bereaved parents:
practical steps in providing compassionate perinatal and neonatal end-of-life care.
A North American perspective. Semin Fetal Neonatal Med. 2008 Oct;13(5):335-40.
109.Kirpalani H, Barks J, Thorlund K, Guyatt G. Cooling for neonatal hypoxic ischemic
encephalopathy: do we have the answer? Pediatrics. 2007 Nov;120(5):1126-30.
110.Bassler D, Ferreira-Gonzalez I, Briel M, Cook DJ, Devereaux PJ, Heels-Ansdell D,
Kirpalani H, Meade MO, Montori VM, Rozenberg A, Schünemann HJ, Guyatt GH.
Systematic reviewers neglect bias that results from trials stopped early for benefit.
J Clin Epidemiol. 2007 Sep;60(9):869-73.
111.Okascharoen C, Hui C, Cairnie J, Morris AM, Kirpalani H. External validation of bedside
prediction score for diagnosis of late-onset neonatal sepsis. J Perinatol. 2007
Aug;27(8):496-501
112.Konduri GG, Vohr B, Robertson C, Sokol GM, Solimano A, Singer J, Ehrenkranz
RA, Singhal N, Wright LL, Van Meurs K, Stork E, Kirpalani H, Peliowski A,
Johnson Y; Neonatal Inhaled Nitric Oxide Study Group. Early inhaled nitric oxide
therapy for term and near-term newborn infants with hypoxic respiratory failure:
neurodevelopmental follow-up. J Pediatr. 2007 Mar;150(3):235-40, 240.e1.
113.Hutchison J, Ward R, Lacroix J, Hébert P, Skippen P, Barnes M, Meyer P,
Morris K, Kirpalani H, Singh R, Dirks P, Bohn D, Moher D; HyP-HIT Investigators;
Canadian Critical Care Trials Group. Hypothermia pediatric head injury trial:
the value of a pretrial clinical evaluation phase. Dev Neurosci. 2006;28(4-5):291-301.
114.Kirpalani H, Whyte RK, Andersen C, Asztalos EV, Heddle N, Blajchman MA,
Peliowski A, Rios A, LaCorte M, Connelly R, Barrington K, Roberts RS. The
Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled
trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low
birth weight infants. J Pediatr. 2006 Sep;149(3):301-307.
115.Schmidt B, Roberts RS, Fanaroff A, Davis P, Kirpalani HM, Nwaesei C, Vincer
M; TIPP Investigators. Indomethacin prophylaxis, patent ductus arteriosus, and
the risk of bronchopulmonary dysplasia: further analyses from the Trial of
Indomethacin Prophylaxis in Preterms (TIPP). J Pediatr. 2006 Jun;148(6):730-734.
116.Parshuram CS, Kirpalani H, Mehta S, Granton J, Cook D; Canadian Critical Care Trials
Group. In-house, overnight physician staffing: a cross-sectional survey of Canadian
adult and pediatric intensive care units. Crit Care Med. 2006 Jun;34(6):1674-8.
117.Kirpalani H, Vanderveen JA. Novel therapies need full outcome assessments.
Indian Pediatr. 2005 Nov;42(11):1081-5.
118.Bassler D, Choong K, McNamara P, Kirpalani H. Neonatal persistent pulmonary
hypertension treated with milrinone: four case reports. Biol Neonate.
2006;89(1):1-5.
119.Monkman SL, Andersen CC, Nahmias C, Ghaffer H, Bourgeois JM, Roberts RS,
Schmidt B, Kirpalani HM. Positive end-expiratory pressure above lower inflection
point minimizes influx of activated neutrophils into lung. Crit Care Med. 2004
Dec;32(12):2471-5.
120.Konduri GG, Solimano A, Sokol GM, Singer J, Ehrenkranz RA, Singhal N, Wright LL,
Van Meurs K, Stork E, Kirpalani H, Peliowski A; Neonatal Inhaled Nitric Oxide Study
Group. A randomized trial of early versus standard inhaled nitric oxide therapy in term
and near-term newborn infants with hypoxic respiratory failure. Pediatrics. 2004
Mar;113(3 Pt 1):559-64.
121.Andersen C, Kent A, Schmidt B, Nahmias C, deSa D, Bourgeois J, Xing Z, Kirpalani H.
Pulmonary fluorodeoxyglucose uptake in infants of very low birth weight with and
without intrauterine inflammation. J Pediatr. 2003 Oct;143(4):470-6.
122.Malik A, Hui CP, Pennie RA, Kirpalani H. Beyond the complete blood cell
count and C-reactive protein: a systematic review of modern diagnostic tests for
neonatal sepsis. Arch Pediatr Adolesc Med. 2003 Jun;157(6):511-6.
123.Monkman S, Kirpalani H. PEEP--a "cheap" and effective lung protection.
Paediatr Respir Rev. 2003 Mar;4(1):15-20.
124.Zupancic JA, Kirpalani H, Barrett J, Stewart S, Gafni A, Streiner D, Beecroft ML, Smith
P. Characterising doctor-parent communication in counselling for impending preterm
delivery. Arch Dis Child Fetal Neonatal Ed. 2002 Sep;87(2):F113-7.
125.Davis PG, Thorpe K, Roberts R, Schmidt B, Doyle LW, Kirpalani H; Trial
Indomethacin Prophylaxis in Preterms Investigators. Evaluating "old" definitions
for the "new" bronchopulmonary dysplasia. J Pediatr. 2002 May;140(5):555-60.
126.Kirpalani H, Asztalos E. Neonatal brain injury. Curr Opin Pediatr. 2001 Jun;
13(3):227-33.
127.Kirpalani HM, Parkin PC, Willan AR, Fehlings DL, Rosenbaum PL, King D, Van
Nie AJ. Quality of life in spina bifida: importance of parental hope. Arch Dis Child. 2000
Oct;83(4):293-7.
128.Matlow AG, Kitai I, Kirpalani H, Chapman NH, Corey M, Perlman M, Pencharz
P, Jewell S, Phillips-Gordon C, Summerbell R, Ford-Jones EL. A randomized trial
of 72- versus 24-hour intravenous tubing set changes in newborns receiving lipid
therapy. Infect Control Hosp Epidemiol. 1999 Jul;20(7):487-93.
129.Fok TF, al-Essa M, Kirpalani H, Monkman S, Bowen B, Coates G, Dolovich M.
Estimation of pulmonary deposition of aerosol using gamma scintigraphy. J Aerosol
Med. 1999 Spring;12(1):9-15.
130.Fok TF, al-Essa M, Dolovich M, Rasid F, Kirpalani H. Nebulisation of surfactants in an
animal model of neonatal respiratory distress. Arch Dis Child Fetal Neonatal Ed. 1998
Jan;78(1):F3-9.
131.Dhar V, Perlman M, Vilela MI, Haque KN, Kirpalani H, Cutz E. Autopsy in a neonatal
intensive care unit: utilization patterns and associations of clinicopathologic
discordances. J Pediatr. 1998 Jan;132(1):75-9.
132.Fok TF, Al-Essa M, Monkman S, Dolovich M, Girard L, Coates G, Kirpalani H.
Pulmonary deposition of salbutamol aerosol delivered by metered dose inhaler,
jet nebulizer, and ultrasonic nebulizer in mechanically ventilated rabbits.
Pediatr Res. 1997 Nov;42(5):721-7.
133.Kirpalani H, Abubakar K, Nahmias C, deSa D, Coates G, Schmidt B.
[18F]fluorodeoxyglucose uptake in neonatal acute lung injury measured by positron
emission tomography. Pediatr Res. 1997 Jun;41(6):892-6.
134.Parkin PC, Kirpalani HM, Rosenbaum PL, Fehlings DL, Van Nie A, Willan AR, King D.
Development of a health-related quality of life instrument for use in children with spina
bifida. Qual Life Res. 1997 Mar;6(2):123-32.
135.Fok TF, al-Essa M, Monkman S, Dolovich M, Girard L, Coates G, Kirpalani H.
Delivery of metered dose inhaler aerosols to paralyzed and nonparalyzed rabbits.
Crit Care Med. 1997 Jan;25(1):140-4.
136.Fok TF, Monkman S, Dolovich M, Gray S, Coates G, Paes B, Rashid F, Newhouse
M, Kirpalani H. Efficiency of aerosol medication delivery from a metered dose
inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia. Pediatr
Pulmonol. 1996 May;21(5):301-9.
137.Mitchell-Dicenso A, Guyatt G, Paes B, Blatz S, Kirpalani H, Fryers M, Hunsberger M,
Pinelli J, Van Dover L, Southwell D. A new measure of parent satisfaction with medical
care provided in the neonatal intensive care unit. J Clin Epidemiol 1996 Mar;49(3):313-8.
138.Broadbent R, Fok TF, Dolovich M, Watts J, Coates G, Bowen B, Kirpalani H.
Chest position and pulmonary deposition of surfactant in surfactant depleted rabbits.
Arch Dis Child Fetal Neonatal Ed. 1995 Mar;72(2):F84-9.
139.Gauldie J, Cox G, Jordana M, Ohno I, Kirpalani H. Growth and colony-stimulating
factors mediate eosinophil fibroblast interactions in chronic airway inflammation. Ann N
Y Acad Sci. 1994 May 28;725:83-90.
140.Schulze A, Schaller P, Töpfer A, Kirpalani H. Measurement of functional residual
capacity by sulfur hexafluoride in small-volume lungs during spontaneous breathing and
mechanical ventilation. Pediatr Res. 1994 Apr;35(4 Pt1):494-9.
141.Xing Z, Jordana M, Kirpalani H, Driscoll KE, Schall TJ, Gauldie J. Cytokine expression
by neutrophils and macrophages in vivo: endotoxin induces tumor necrosis factor-alpha,
macrophage inflammatory protein-2, interleukin-1 beta, and interleukin-6 but not
RANTES or transforming growth factor-beta 1 mRNA expression in acute lung
inflammation. Am J Respir Cell Mol Biol. 1994 Feb;10(2):148-53. Erratum in: Am J
Respir Cell Mol Biol 1994 Mar;10(3):following 346.
142.Xing Z, Kirpalani H, Torry D, Jordana M, Gauldie J. Polymorphonuclear leukocytes as a
significant source of tumor necrosis factor-alpha in endotoxin-challenged lung tissue.
Am J Pathol. 1993 Oct;143(4):1009-15.
143.Schulze A, Schaller P, Töpfer A, Kirpalani H. Resistive and elastic unloading to assist
spontaneous breathing does not change functional residual capacity. Pediatr Pulmonol.
1993 Sep;16(3):170-6.
144.Andrew M, Vegh P, Caco C, Kirpalani H, Jefferies A, Ohlsson A, Watts J, Saigal S,
Milner R, Wang E. A randomized, controlled trial of platelet transfusions in
thrombocytopenic premature infants. J Pediatr. 1993 Aug;123(2):285-91.
145.MacKinnon JA, Perlman M, Kirpalani H, Rehan V, Sauve R, Kovacs L. Spinal cord
injury at birth: diagnostic and prognostic data in twenty-two patients. J Pediatr. 1993
Mar;122(3):431-7.
146.Low DE, Schmidt BK, Kirpalani HM, Moodie R, Kreiswirth B, Matlow A, Ford-Jones EL.
An endemic strain of Staphylococcus haemolyticus colonizing and causing bacteremia
in neonatal intensive care unit patients. Pediatrics. 1992 Apr;89(4 Pt 2):696-700.
147.Perlman NB, Freedman JL, Abramovitch R, Whyte H, Kirpalani H, Perlman M.
Informational needs of parents of sick neonates. Pediatrics. 1991 Sep;88(3):512-8.
148.Kirpalani H, Kechagias S, Lerman J. Technical and clinical aspects of capnography in
neonates. J Med Eng Technol. 1991 Jul-Oct;15(4-5):154-61.
149.Kirpalani H, Schmidt B, Gaston S, Santos R, Wilkie R. Birthweight, early passive
respiratory system mechanics, and ventilator requirements as predictors of outcome in
premature infants with respiratory failure. Pediatr Pulmonol. 1991;10(3):195-8.
150.Kirpalani H, Koren G, Schmidt B, Tan Y, Santos R, Soldin S. Respiratory response and
pharmacokinetics of intravenous salbutamol in infants with bronchopulmonary
dysplasia. Crit Care Med. 1990 Dec;18(12):1374-7.
151.Lui K, Boag G, Daneman A, Costello S, Kirpalani H, Whyte H. Widened subarachnoid
space in pre-discharge cranial ultrasound: evidence of cerebral atrophy in immature
infants? Dev Med Child Neurol. 1990 Oct;32(10):882-7
152.Baboolal R, Kirpalani H. Measuring on-line compliance in ventilated infants using hot
wire anemometry. Crit Care Med. 1990 Oct;18(10):1070-2.
153.McEvedy BA, McLeod ME, Kirpalani H, Volgyesi GA, Lerman J. End-tidal carbon
dioxide measurements in critically ill neonates: a comparison of side-stream and
mainstream capnometers. Can J Anaesth. 1990 Apr;37(3):322-6.
154.Kirpalani H, Schmidt B, McKibbon KA, Haynes RB, Sinclair JC. Searching MEDLINE for
randomized clinical trials involving care of the newborn. Pediatrics 1989 Apr;83(4):543-6.
155.Silver MM, Cave CT, Kirpalani H. Case 6. Perinatal hemochromatosis. Pediatr
Pathol. 1989;9(2):203-10.
156.Kirpalani H, Santos-Lyn R, Roberts R. Some infant ventilators do not limit peak
inspiratory pressure reliably during active expiration. Crit Care Med. 1988
Sep;16(9):880-3.
157.McEvedy BA, McLeod ME, Mulera M, Kirpalani H, Lerman J. End-tidal, transcutaneous,
and arterial pCO2 measurements in critically ill neonates: a comparative study.
Anesthesiology. 1988 Jul;69(1):112-6.
158.Kohelet D, Perlman M, Kirpalani H, Hanna G, Koren G. High-frequency oscillation in the
rescue of infants with persistent pulmonary hypertension. Crit Care Med. 1988
May;16(5):510-6.
159.Koren G, Long D, Klein J, Beatie D, Bologa-Campeanu M, Livne A, Kirpalani H.
Comparison of the digitalis receptor in erythrocytes from preterm infants and adults.
Pediatr Res. 1988 Apr;23(4):414-7.
160.Schmidt B, Kirpalani H, Rosenbaum P, Cadman D. Strengths and limitations of the
Apgar score: a critical appraisal. J Clin Epidemiol. 1988;41(9):843-50.
161.Schmidt BK, Kirpalani HM, Corey M, Low DE, Philip AG, Ford-Jones EL.
Coagulase-negative staphylococci as true pathogens in newborn infants: a cohort
study. Pediatr Infect Dis J. 1987 Nov;6(11):1026-31.
162.Kirpalani H, Higa T, Perlman M, Friedberg J, Cutz E. Diagnosis and therapy of
necrotizing tracheobronchitis in ventilated neonates. Crit Care Med. 1985
Oct;13(10):792-7.
163.Campbell AN, Lightstone AD, Smith JM, Kirpalani H, Perlman M. Mechanical
vibration and sound levels experienced in neonatal transport. Am J Dis Child.
1984 Oct;138(10):967-70.
164.Pearson AD, Kirpalani H, Ashcroft T, Bain H, Craft AW. Lymphomatoid granulomatosis
in a 10 year old boy. Br Med J (Clin Res Ed). 1983 Apr 23;286(6374):1313-4.
165.Eastham EJ, Kirpalani H, Francis D, Gokal R, Jackson RH. Paediatric continuous
ambulatory peritoneal dialysis. Arch Dis Child. 1982 Sep;57(9):677-80.
Contributions to peer-reviewed clinical research publications as collaborator rather
than named author: N = 32
There are 32 publications indexed in Pubmed for which I am listed as collaborator rather than
named author. I contributed to these publications as site investigator for multi-center clinical
research studies and research networks, or as a member of the Data Safety Monitoring Board.
Book Chapters, Commentaries, Editorials, Letters and Practice Guidelines: N = 36
1. Kirpalani HM, Prokopchuk-Gauk O, Heddle NM. Use of Irradiated Red Blood Cell
Transfusions in Newborns to Improve Intracerebral Saturation. JAMA Pediatr. 2022 May
1; 176(5):e220149.
2. Kirpalani H. Can We Predict Bronchopulmonary Dysplasia Early in Life? Neonatology
2021; 118(4):479-481.
3. Burris HH, Hwang SS, Collins JW Jr, Kirpalani H, Wright CJ. Re-conceptualizing
Associations between Race and Morbidities of Extreme Prematurity. J Pediatr. 2019
Apr;207:10-14.e1.
4. Manja V, Kirpalani H, Lakshminrusimha S. Factors influencing decision-making:
Delayed hypothermia in a late preterm infants with hypoxic-ischemic
encephalopathy. Early Hum Dev. 2019 Jan;128:102-103.
5. Hwang SS, Burris HH, Collins JW Jr, Kirpalani H, Wright CJ. Moving beyond race and
ethnicity to understand the effect of inhaled nitric oxide on bronchopulmonary dysplasia
prevention. J Pediatr. 2018 Oct;201:298-300.
6. Kirpalani H, Stark MJ, Andersen C. On the Gendering of Plasma: What is
Transfusion-Related Acute Lung Injury to Bronchopulmonary Dysplasia? J Pediatr.
2018 Oct; 201:12-13.
7. Kirpalani H, Whyte R. The tangled duo of anaemia and transfusion travel together, that
is the problem. Acta Paediatr. 2018 May;107(5):730-731.
8. Siemieniuk RAC, Lytvyn L, Mah Ming J, Mullen RM, Anam F, Otieno T, Guyatt GH,
Taylor GP, Beltrán-Arroyave C, Okwen PM, Nduati R, Kinuthia J, Luma HN, Kirpalani H,
Merglen A, Lesi OA, Vandvik PO, Agoritsas T, Bewley S. Antiretroviral therapy in
pregnant women living with HIV: a clinical practice guideline. BMJ. 2017 Sep 11;
358:j3961.
9. Wright CJ, Norman M, Kirpalani H, Johansson S. EBNEO commentaries in Acta
Paediatrica: a new collaboration to advance evidence-based neonatology. Acta
Paediatr. 2017 Mar;106(3):358.
10.Yoder BA, Kirpalani H. Noninvasive Ventilation. Clin Perinatol. 2016 Dec;43(4)
11.Foglia EE, Owen LS, Keszler M, Davis PG, Kirpalani H. Obtaining informed consent for
delivery room research: the investigators' perspective. Arch Dis Child Fetal Neonatal
Ed. 2017 Jan;102(1):F90-F91.
12.Wright CJ, Kirpalani H. When should we start continuous positive airway pressure in the
delivery room and how high should we go? Acta Paediatr. 2016 Aug;105(8):868-70.
13.Jensen EA, Kirpalani H. Non-invasive respiratory support. Semin Fetal Neonatal Med.
2016 Jun;21(3):133-4.
14.Kirpalani H, Zupancic J. "Waste not, want not", or the cost of doing the wrong thing. J
Pediatr (Rio J). 2016 Jan-Feb;92(1):1-3.
15.Foglia EE, Owen LS, Kirpalani H. Delivery room research: when does poor quality
evidence become an ethical issue? Pediatrics. 2015 May;135(5):e1368.
16.Posencheg M, Kirpalani H. Placental transfusion at birth: do we have all of the
answers? JAMA Pediatr. 2015 Jan;169(1):9-11.
17.Jensen EA, Kirpalani H. Inhaled nitric oxide to prevent bronchopulmonary dysplasia in
preterm infants--less than a silver bullet. J Pediatr. 2014 Dec;165(6):1079-81
18.Jensen EA, DeMauro SB, Kirpalani H. Has enough evidence accumulated to consider
CPAP a first-line standard of care in developing countries? Arch Dis Child Fetal
Neonatal Ed. 2014 Nov;99(6):F443-4.
19.Foglia EE, Kirpalani H, DeMauro SB. Long-term respiratory morbidity in preterm infants:
is noninvasive support in the delivery room the solution? J Pediatr. 2014
Aug;165(2):222-5.
20.Demauro SB, Dysart K, Kirpalani H. Stopping the swinging pendulum of postnatal
corticosteroid use. J Pediatr. 2014 Jan;164(1):9-11.
21.Simma B, Kirpalani H. Sodium bicarbonate--the swings and roundabouts will not stop
without randomized evidence. Crit Care Med. 2013 Sep;41(9):2242-3.
22.Giaccone A, Kirpalani H. Judgment often impossible without randomized trials.
Commentary on N. Patel: use of milrinone to treat cardiac dysfunction in infants with
pulmonary hypertension secondary to congenital diaphragmatic hernia: a review of six
patients (Neonatology 2012;102:130-136). Neonatology. 2012;102(2):137-8.
23.Dysart KC, Kirpalani HM, Wusthoff CJ, Seshia SS. Amplitude-integrated
electroencephalography: a runaway horse? Can J Neurol Sci. 2012 May;39(3):267-8.
24.Kirpalani H, Whyte R. Truths, associations, and hypotheses. J Pediatr. 2011
Sep;159(3):359-61.
25.Sun B, Kirpalani H. Development of neonatal respiratory support and intensive care in
emerging regions of China. Chin Med J (Engl). 2010 Oct;123(20):2757-8.
26.Kirpalani H, Nahmias C. Radiation risk to children from computed tomography.
Pediatrics. 2008 Feb;121(2):449-50.
27.Kirpalani H, Vanderveen JA. Novel therapies need full outcome assessments. Indian
Pediatr. 2005 Nov;42(11):1081-5.
28.Puntis JW, Kirpalani H. Letter from Puntis. J Clin Forensic Med. 2005 Jun;12(3):167
29.Kirpalani H. Neonatal lung disease. Paediatr Respir Rev. 2003 Mar;4(1):1.
30.Kabra NS, Kirpalani H. Blood transfusions in the premature nursery. Indian Pediatr.
2002 Jul;39(7):619-24.
31.Puntis J, Kirpalani H. Hunger strikes in Turkey. Lancet. 2001 Apr 14;357(9263):1210.
32.Kirpalani H. Alpha1-proteinase inhibitor in the newborn - A comment. Can Respir J.
1999 Mar-Apr;6(2):136-7.
33.Puntis J, Kirpalani H. Reappraisal of Malthus. Lancet. 1998 Jul 18;352(9123):241-2.
34.Guyatt G, Kirpalani H. Health care in Canada. N Engl J Med. 1992 Nov
26;327(22):1603.
35.Woodside D, Oxman A, Berger P, Kirpalani H. The Medical reform Group has a
purpose. CMAJ. 1990 Sep 1;143(5):368-9.
36.Kirpalani H, Perlman M, Friedberg J, Cuaz E. Necrotizing tracheobronchitis.
Pediatrics. 1986 Dec;78(6):1167-8.
BACKGROUND
Personal Statement
I am an emeritus professor at both University Pennsylvania, USA and McMaster University, Canada. I am a neonatal physician trained from medical school to advanced fellow status in the UK; with further training at Toronto Hospital Sick Children, Canada. I am MSc qualified in Clinical Epidemiology (McMaster University). At McMaster University, I helped establish the Neonatal Research group out of the Department of Clinical Epidemiology & Biostatistics (led and co-founded by myself, Barbara Schmidt, and Robin Roberts). Since 2007 I worked mainly in the USA at The Children’s Hospital of Philadelphia. I was the founding Director of the Chronic Lung Disease Program at Children’s Hospital of Philadelphia. I am committed to mentoring junior researchers and clinicians. I was fortunate to receive several teaching and mentoring awards – the last being in 2015 – an award for Junior Faculty mentoring at Children’s Hospital Philadelphia. I have been involved with randomized controlled trials (RCT) in either the neonatal ICU or the pediatric ICU since 1985. This involvement includes service on several data safety monitoring committees for RCTs. I remain a passionate advocate of Evidence Based Medicine in neonatal trials, which I interpret as an imperative to have more high quality randomized evidence of therapies in the NICU. I was on the foundation editorial founding board of an international organization “Evidence Based Neonatology” (https://ebneo.org/).
Prior RCT work was funded by the Canadian Institute of Health Research (CIHR) and I then held current NIHCHD and NHLBI funding. I was also the alternate PI to the Neonatal Research Network of the NICHD at the University of Pennsylvania, of which Dr. Barbara Schmidt was the PI. My RCT experience began in 1985, as the trial coordinator at the Hospital for Sick Children for the High Frequency Oscillation (HiFi) study. I was a steering committee member for 2 major neonatal trials of inhaled nitric oxide funded by the Canadian Institute of Health Research and in which the Neonatal Research Network of the NICHD took part: the Neonatal Inhaled Nitric Oxide Study (NiNOS) and the Early Inhaled Nitric Oxide Study (EiNOS) trials. I was the PI of a multinational randomized controlled trial – funded by Canadian Institute of Health Research (CIHR): Nasal Intermittent Positive Pressure Ventilation trial NIPPV - comparing CPAP vs nasal IPPV non-invasive respiratory support, which enrolled 1012 infants of BW <1000 g.
I was the PI of a multi-national trial on the effects of Sustained Inflation in the delivery room in preterms (Sustained Aeration of Infant Lungs (SAIL) trial: study protocol for a randomized controlled trial). This is now published JAMA 2019 (see below), and has explicitly informed and been quoted by the most recent European Guidelines for resuscitation. I was also the PI of the Preterms In Need of Transfusion (PINT) study, funded by the CIHR. This was the largest neonatal RCT to examine whether random allocation to two different hemoglobin thresholds affect clinically relevant neonatal outcomes in infants with birth weights <1000 g. A further CIHR funded project (PINT-Outcome Study) followed these infants to 24 months to assess longer term outcomes. The PINT-Outcome trial, in secondary post-hoc analyses, showed a possible benefit to a higher hemoglobin regimen. That set the stage for the large trial “Transfusion of Prematurity (TOP trial). I was the contact PI of the TOP trial, funded by NHLBI to randomize 1824 babies <1000 g BW to high or low hemoglobin transfusion thresholds. TOP had a primary outcomes of death or neurodevelopment by 2 years of age. The TOP trial was published in the NEJM as listed below.
1. Kirpalani H, Bell EF, Hintz SR, Tan S, Schmidt B, Chaudhary AS, Johnson KJ, Crawford MM, Newman JE, Vohr BR, Carlo WA, D'Angio CT, Kennedy KA, Ohls RK, Poindexter BB, Schibler K, Whyte RK, Widness JA, Zupancic JAF, Wyckoff MH, Truog WE, Walsh MC, Chock VY, Laptook AR, Sokol GM, Yoder BA, Patel RM, Cotten CM, Carmen MF, Devaskar U, Chawla S, Seabrook R, Higgins RD, Das A; Eunice Kennedy Shriver NICHD Neonatal Research Network. Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants. N Engl J Med. 2020 Dec 31;383(27):2639-2651
2. Kirpalani H, Ratcliffe SJ, Keszler M, Davis PG, Foglia EE, Te Pas A, Fernando M, Chaudhary A, Localio R, van Kaam AH, Onland W, Owen LS, Schmölzer GM, Katheria A, Hummler H, Lista G, Abbasi S, Klotz D, Simma B, Nadkarni V, Poulain FR, Donn SM, Kim HS, Park WS, Cadet C, Kong JY, Smith A, Guillen U, Liley HG, Hopper AO, Tamura M; SAIL Site Investigators. Effect of Sustained Inflations vs Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants: The SAIL Randomized Clinical Trial. JAMA. 2019 Mar 26;321(12):1165-1175.
3. Kirpalani H, Millar D, Lemyre B, Yoder BA, Chiu A, Roberts RS; NIPPV Study Group. A trial comparing noninvasive ventilation strategies in preterm infants. N Engl J Med. 2013 Aug15; 369(7): 611-20.
4. Kirpalani H, Whyte RK, Andersen C, Asztalos EV, Heddle N, Blajchman MA, Peliowski A, Rios A, LaCorte M, Connelly R, Barrington K, Roberts RS. The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr. 2006 Sep; 149(3):301-307.
